Product Name	ARPC1B
Chinese Name	肌动蛋白相关蛋白2/3复合亚单位B1抗体
Alias	ARC1B_HUMAN; Actin-related protein 2/3 complex subunit 1B; ARC41; Arp2/3 complex 41 kDa subunit; p41-ARC; actin related protein 2/3 complex subunit 1B; IMD71; PLTEID; p40-ARC;
literatures	Specific References  (1)     |     SL10563R has been referenced in 1 publications. [IF=3.698] Weimin Ni. et al. Actin Related Protein 2/3 Complex Subunit 1 up-regulation in the hypothalamus prevents high-fat diet induced obesity. EUR J NEUROSCI. 2022 Nov;:  IF ;  Mouse.   PubMed:36382618
Research Area	Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ARPC1B: 101-200/372
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Subcellular Location: Cytoplasm, cytoskeleton. Similarity: Belongs to the WD repeat ARPC1 family. Contains 6 WD repeats. SWISS: O15143 Gene ID: 10095 Database links: Entrez Gene: 10095 Human Entrez Gene: 11867 Mouse Omim: 604223 Human SwissProt: O15143 Human SwissProt: Q9WV32 Mouse Unigene: 489284 Human Unigene: 30010 Mouse

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