Product Name	HDC
Chinese Name	L-组氨酸脱羧酶抗体
Alias	L-Histidine decarboxylase; EC 4.1.1.22; HDC; L-HDC; Histidine decarboxylase; DCHS_HUMAN.
Research Area	immunology  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	74kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDC: 351-450/662
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Histidine decarboxylase(HDC) is the enzyme that calalyses the conversion of histidine into histamine. It can be found in the histamine secreting ECL cells of some species, as well as in the mast cells.The biogenic amine histamine is an important modulator of numerous physiological processes, including neurotransmission, gastric acid secretion and smooth muscle tone. Function: Catalyzes the biosynthesis of histamine from histidine. Subunit: Homodimer. Similarity: Belongs to the group II decarboxylase family. SWISS: P19113 Gene ID: 3067 Database links: Entrez Gene: 3067 Human Entrez Gene: 15186 Mouse Entrez Gene: 24443 Rat Omim: 142704 Human SwissProt: P19113 Human SwissProt: P23738 Mouse SwissProt: P16453 Rat Unigene: 1481 Human Unigene: 18603 Mouse Unigene: 48653 Rat 主要用于多种变态反应及炎性浸润改变有关的研究。
Product Picture	Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-HDC Polyclonal Antibody, Unconjugated(SL1054R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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