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Product Name valyl tRNA Chinese Name 缬氨酰-tRNA合成酶抗体 Alias SYVM_HUMAN; Valine--tRNA ligase, mitochondrial; Valyl-tRNA synthetase; ValRS; Valyl-tRNA synthetase-like; valyl tRNA; VARS2; KIAA1885; VARS2L; VARSL. Research Area Cell biology immunology Synthesis and Degradation Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 115kDa Cellular localization cytoplasmic Mitochondrion Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human vars2 : 1-100/1063 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail ValRS (valyl-tRNA synthetase), also known as Protein G7a, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins, LeuRS and IleRS. These proteins are large monomeric proteins and play a major role in catalyzing the aminoacylation of tRNA by their cognate amino acid. ValRS joins Val to tRNA(Val) at its synthetic active site. At its CP1 editing active site, ValRS hydrolyzes or deacylates tRNA(Thr) that is incorrectly joined to Val. ValRS forms aggregates with EF-1 (elongation factor 1) and, via this complex, catalyzes the aminoacylation of tRNA and its transfer to EF-1. In addition, ValRS may be regulated by PKC-dependent phosphorylation.
Subcellular Location:
Mitochondrion (Potential).
Similarity:
Belongs to the class-I aminoacyl-tRNA synthetase family.
SWISS:
P26640
Gene ID:
7407
Database links:Entrez Gene: 7407 Human
Omim: 192150 Human
SwissProt: P26640 Human
Unigene: 520026 Human
Unigene: 12314 Rat
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