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Product Name Minibrain Chinese Name Minibrain 抗体 Alias MNB_DROME; Serine/threonine-protein kinase minibrain; mnb; Dmel_CG42273; Dmel_CG7826; Dmel_CG7835; CG42273; CG7826; CG7835; Dm1; Dmel\CG42273; Dyrk1; DYRK1; ME-IV; min; Mnb; MNB. Research Area Insect Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Fruit Fly, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 96kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Fruitfly Minibrain: 1-100/908 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Function:
Role in the specific control of proper proliferation of optic lobe neuronal progeny.
Subcellular Location:
Nucleus (Potential).
Tissue Specificity:
In ventral nerve cord and supraesophageal ganglion of embryos. Is most prominent in the mushroom body neuropil and the outer proliferation center of the optic lobes in third instar larvae.
Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Contains 1 protein kinase domain.
SWISS:
P49657
Gene ID:
32771
Database links:Entrez Gene: 32771 DROME
SwissProt: P49657 Fruit Fly
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