Product Name	GGT2 light chain
Chinese Name	γ谷氨酰转肽酶2轻链抗体
Alias	GGT 2; GGT-2; Gamma-glutamyltranspeptidase 2 light chain; Gamma glutamyltranspeptidase 2; gamma-glutamyltranspeptidase; GGT2_HUMAN.GGT 2; Glutathione hydrolase 2; Gamma-glutamyltranspeptidase 2.
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Horse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Gamma-glutamyltranspeptidase 2 light chain: 451-550/569 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	GGT acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. Function: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Highly expressed in fetal and adult kidney and liver. Similarity: Belongs to the gamma-glutamyltransferase family. SWISS: P36268 Gene ID: 728441 Database links: Entrez Gene: 728441 Human SwissProt: P36268 Human

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