Product Name	MGST1
Chinese Name	微粒体谷胱甘肽S转移酶1抗体
Alias	MGST1; Glutathione S transferase 12; Microsomal glutathione transferase 1; GST12; MGST 1; MGST; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I.
Research Area	Neurobiology  Signal transduction  Alzheimer's
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MGST1: 21-100/155
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Subcellular Location: Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in liver. Post-translational modifications: Peroxynitrite induces nitration at Tyr-93 which activates the enzyme. Similarity: Belongs to the MAPEG family. SWISS: P10620 Gene ID: 4257 Database links: Entrez Gene: 4257 Human Entrez Gene: 56615 Mouse Entrez Gene: 171341 Rat Omim: 138330 Human SwissProt: P10620 Human SwissProt: Q91VS7 Mouse SwissProt: P08011 Rat Unigene: 389700 Human Unigene: 14796 Mouse Unigene: 2580 Rat

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