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Product Name chemerin Chinese Name 趋化素抗体 Alias Rarres2; TIG2; tazarotene induced gene 2; Retinoic acid receptor responder protein 2; Tazarotene-induced gene 2 protein; RAR-responsive protein TIG2; Chemerin. literatures Specific References (5) | SL10410R has been referenced in 5 publications.[IF=5.52] Gonzalvo-Feo, Safiye, et al. "Endothelial Cell–Derived Chemerin Promotes Dendritic Cell Transmigration." The Journal of Immunology (2014): 1302028. Mouse.[IF=4.43] Akamata, Kaname, et al. "Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis." Rheumatology (2014): keu479. IHC-P ; Human.[IF=3.647] Lin Zhu. et al. Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1. Life Sci. 2021 Aug;278:119530 Human.[IF=3.448] Hanthazi A et al. Chemerin influences endothelin-and serotonin-induced pulmonary artery vasoconstriction in rats. Life Sci. 2019 Jun 16:116580. IHC-P ; Rat.[IF=2.13] Krautbauer, Sabrina, et al. "Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver." Experimental and molecular pathology (2013). Mouse.Research Area Tumour Cardiovascular Signal transduction Lipoprotein The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Pig, Cow, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 18kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rabbit chemerin: 101-163/163 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Chemerin, also known as retinoic acid receptor responder 2 (RARRES2) and tazarotene induced gene 2 (TIG2), is a chemoattractant protein for cells expressing G-protein-linked receptor chemokine-like receptor 1 (CMKLR1, ChemR23 or GPCR-DEZ). The protein is synthesized as a secreted precursor, prochemerin (18 kDa), which is poorly active. Upon proteolytic removal of the last six amino acids, prochemerin is converted into mature active chemerin (15-16 kDa) that acts as a strong and highly specific agonist of its receptor CMKLR1. Chemerin is a newly described adipokine with effects on adipocyte differnetiation and metabolism.
Subcellular Location:
Secreted (Potential).
Tissue Specificity:
Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon.
SWISS:
Q99969
Gene ID:
5919
Database links:Entrez Gene: 5919 Human
Omim: 601973 Human
SwissProt: Q99969 Human
Unigene: 647064 Human
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