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Product Name HBeAg Chinese Name 乙型肝炎e抗原抗体 Alias External core antigen; Precore protein; p25; C; HBEAG_HBVD3; Research Area Cell biology immunology Signal transduction Growth factors and hormones transcriptional regulatory factor lymphocyte Immunogen Species Rabbit Clonality Polyclonal Applications ELISA=1:5000-10000 IHC-F=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 12kDa Cellular localization cytoplasmic Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HBeAg: 51-212/212 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into “hiding,” the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of antibodies against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.
Function:
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
Subunit:
Homodimerizes.
Subcellular Location:
Secreted. Host nucleus.
Post-translational modifications:
Phosphorylated.
Cleaved by host furin.
Similarity:
Belongs to the orthohepadnavirus precore antigen family.
SWISS:
P0C573
Gene ID:
N/A
Database links:SwissProt: Q89714 Hepatitis B virus
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