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Product Name FGFR substrate 3 Chinese Name 纤维母细胞生长因子受体底物3抗体 Alias FGFR signalling adaptor SNT2; FGFR substrate 3; Fibroblast growth factor receptor substrate 3; FRS2 beta; FRS2B; FRS3; FRS3 protein; MGC17167; SNT 2; Suc1 associated neurotrophic factor target 2 (FGFR signalling adaptor); Suc1 associated neurotrophic factor target 2; FRS3_HUMAN; FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2. Research Area Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 54kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FGFR substrate 3: 401-492/492 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008].
Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Subunit:
Binds NTRK1. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.
Subcellular Location:
Membrane; Lipid-anchor.
Tissue Specificity:
Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
Similarity:
Contains 1 IRS-type PTB domain.
SWISS:
O43559
Gene ID:
10817
Database links:Entrez Gene: 10817 Human
Entrez Gene: 107971 Mouse
Omim: 607744 Human
SwissProt: O43559 Human
SwissProt: Q91WJ0 Mouse
Unigene: 194208 Human
Unigene: 34398 Rat
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