Product Name	TBCEL
Chinese Name	微管蛋白折叠辅助因子E样抗体
Alias	EL; Leucine-rich repeat-containing protein 35; LRRC35; TBCEL; TBCEL_HUMAN; Tubulin folding cofactor E-like; Tubulin-specific chaperone cofactor E-like protein.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TBCEL: 1-100/424
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TBCEL is a 424 amino acid cytoplasmic protein that acts as a regulator of tubulin stability. While abundantly expressed in testis, TBCEL is also present in several tissues at a much lower level. TBCEL contains seven LRR (leucine-rich) repeats, one LRRCT domain and one ubiquitin-like domain. The gene that encodes TBCEL consists of 66,704 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11. Function: Acts as a regulator of tubulin stability. Subcellular Location: Cytoplasm > cytoskeleton. Tissue Specificity: Abundantly expressed in testis, but is also present in several tissues at a much lower level. Similarity: Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 ubiquitin-like domain. SWISS: Q5QJ74 Gene ID: 219899 Database links: Entrez Gene: 219899 Human Omim: 610451 Human SwissProt: Q5QJ74 Human Unigene: 504136 Human
Product Picture	Sample: Lane 1: U-2OS (Human) Cell Lysate at 30 ug Lane 2: HUVEC (Human) Cell Lysate at 30 ug Lane 3: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 4: HL-60 (Human) Cell Lysate at 30 ug Lane 5: Cerebrum (Mouse) Lysate at 40 ug Lane 6: Cerebrum (Rat) Lysate at 40 ug Lane 7: Kidney (Mouse) Lysate at 40 ug Lane 8: Testis (Mouse) Lysate at 40 ug Lane 9: Testis (Rat) Lysate at 40 ug Lane 10: Stomach (Rat) Lysate at 40 ug Primary: Anti-TBCEL (SL10292R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD

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