Product Name	PHB2
Chinese Name	B细胞受体相关蛋白抗体
Alias	PHB2_HUMAN; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity; BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141;
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PHB2: 281-299/299
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022] Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. Subunit: Interacts with PHB, ESR1, HDAC1 and HDAC5. Interacts with ZNF703. Subcellular Location: Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear. Similarity: Belongs to the prohibitin family. SWISS: Q99623 Gene ID: 11331 Database links: Entrez Gene: 11331 Human Entrez Gene: 12034 Mouse Entrez Gene: 114766 Rat Omim: 610704 Human SwissProt: Q99623 Human SwissProt: O35129 Mouse SwissProt: Q5XIH7 Rat Unigene: 504620 Human Unigene: 36241 Mouse Unigene: 64535 Rat
Product Picture	Protein: spleen(mouse) lysate at 40ug; Primary: rabbit Anti-REA (SL10283R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000; Predicted band size: 33 kD Observed band size: 35 kD Sample: heart (Mouse) Lysate at 40 ug Primary: Anti-REA (SL10283R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 33 kD Tissue/cell: colonic epithelial cells; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-REA Polyclonal Antibody, Unconjugated(SL10283R) 1:100, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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