Product Name	Neuropilin 2/NRP2
Chinese Name	神经纤毛蛋白2抗体
Alias	NRP2; MGC126574; Neuropilin 2; Neuropilin-2; Neuropilin2; NP 2; NP2; NPN 2; NPN2; NRP 2; nrp2; PRO2714; Receptor for VEGF165 and semaphorins class3; Vascular endothelial growth factor 165 receptor 2; VEGF1265R2; NRP2_HUMAN; Vascular endothelial growth factor 165 receptor 2; VEGF165R2.
literatures	Specific References  (2)     |     SL10241R has been referenced in 2 publications. [IF=1.267] Danhui Yin. et al. Clinical significance of neuropilin-2 expression in laryngeal squamous cell carcinoma. Am J Otolaryng. 2020 Jul;41:102540  WB ;  Human.   PubMed:32480134 [IF=0] Briscoe DM et al. METHODS AND COMPOSITIONS FOR IMMUNOMODULATION. US Patent 20190388505  FCM ;  Mouse&Human.   PubMed:US Patent 20190388505
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	99kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Neuropilin 2: 501-600/931 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Subunit: Heterodimer with NRP1. Binds PLXNB1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. Similarity: Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain. SWISS: O60462 Gene ID: 8828 Database links: Entrez Gene: 8828 Human Entrez Gene: 18187 Mouse Entrez Gene: 81527 Rat Entrez Gene: 374157 Chicken Entrez Gene: 541004 Cow Omim: 602070 Human SwissProt: O60462 Human SwissProt: O35375 Mouse SwissProt: O35276 Rat Unigene: 471200 Human Unigene: 266341 Mouse Unigene: 10816 Rat
Product Picture	Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Neuropilin 2/NRP2 Polyclonal Antibody, Unconjugated(SL10241R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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