Product Name	Phospho-ELk1 (Ser383)
Chinese Name	磷酸化细胞转录因子ELK1抗体
Alias	ELK1 (phospho S383); Elk-1(Phospho-Ser383); p-ELK1 (S383); p-Elk-1(Ser383); ELK 1; ELK1 member of ETS oncogene family; ELK1 protein; ELK2 member of ETS oncogene family; ETS domain containing protein Elk 1; ETS domain containing protein Elk1; ETS domain protein Elk1; Oncogene Elk1; ETS domain-containing protein Elk-1 isoform a; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene; ELK1_HUMAN.
literatures	Specific References  (1)     |     SL10154R has been referenced in 1 publications. [IF=5.157] Yubing Yu. et al. Angiogenic factor AGGF1 Blocks Neointimal Formation after Vascular Injury via Interaction with Integrin α7 on Vascular Smooth Muscle Cells. J Biol Chem. 2022 Feb;:101759  WB ;  Mouse.   PubMed:10.1016/j.jbc.2022.101759
Product Type	Phosphorylated anti
Research Area	Tumour  transcriptional regulatory factor  Kinases and Phosphatases  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human ELk1 around the phosphorylation site of Ser383: TL(p-S)PI
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]. Function: Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element. Subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. Subcellular Location: Nucleus. Tissue Specificity: Lung and testis. Post-translational modifications: Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. SWISS: P19419 Gene ID: 2002 Database links: Entrez Gene: 2002 Human Entrez Gene: 13712 Mouse Entrez Gene: 314436 Rat Omim: 311040 Human SwissProt: P19419 Human SwissProt: P41969 Mouse Unigene: 181128 Human Unigene: 405823 Mouse Unigene: 30029 Rat
Product Picture	Sample: K562 Cell (Human) Lysate at 40 ug Primary: Anti-Phospho-ELk1(Ser383) (SL10154R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 48 kD Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-Phospho-ELk1(Ser383) (SL10154R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 49 kD Sample: Hela Cell (Human) Lysate at 40 ug 293T Cell (Human) Lysate at 40 ug Primary: Anti- Phospho-ELk1(Ser383) (SL10154R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 47 kD

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