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Product Name Tuftsin Chinese Name 吞噬刺激肽抗体 Alias Phagocytosis-stimulating peptide; Tuftsin; TUFT_HUMAN; TKPR; Research Area Tumour immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 0.5kDa Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TKPR (Tuftsin) Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail 促吞噬肽(Tuftsin)是一种仅产生于脾脏的四肽物质,具有免疫调节作用。国内外已有部分实验证明了其抗Tumour作用。国外已开始将人工合成的tuftsin用于治疗晚期恶性Tumour、AIDS病患者。
tuftsin是机体自然存在的免疫四肽。1973年Najjar等人工合成tuftsin并证实人工合成品与天然四肽具有相同的理化性质和生物学特性。由于脾切除以后,这种物质明显减少,甚至消失,故认为这种物质是由脾脏产生的。tuftsin不仅作用于中性粒细胞而且还作用于巨噬细胞、NK细胞等,既有抗感染作用,又有抗Tumour作用。目前国外已将人工合成的tuftsin用于某些晚期Tumour及AIDS病的治疗,并取得了一定的疗效。
抗Tumour作用主要表现如 :
①增强巨噬细胞的吞噬功能。
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