Product Name	CD35
Chinese Name	Ⅰ型补体受体（C3b/C4b受体）抗体
Alias	C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen.
literatures	Specific References  (2)     |     SL10144R has been referenced in 2 publications. [IF=7.097] Jinyang Li. et al. A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated. Acta Pharm Sin B. 2021 Jan;11:283  IF ;  Mouse.   PubMed:33532193 [IF=5.23] Rovituso, Damiano M., et al. "CEACAM1 mediates B cell aggregation in central nervous system autoimmunity." Scientific Reports 6 (2016): 29847.  IHC-P ;  Mouse.   PubMed:27435215
Research Area	immunology  The cell membrane受体  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	274kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CR1/CD35: 1301-1400/2039
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] Function: Mediates cellular binding of particles and immune complexes that have activated complement. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. Similarity : Belongs to the receptors of complement activation (RCA) family. Contains 30 Sushi (CCP/SCR) domains. SWISS: P17927 Gene ID: 1378 Database links: Entrez Gene: 1378 Human Omim: 120620 Human SwissProt: P17927 Human Unigene: 334019 Human CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合Transmembrane protein，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD35) Polyclonal Antibody, Unconjugated (SL10144R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Tissue/cell: Rat spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CD35 Polyclonal Antibody, Unconjugated(SL10144R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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