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Product Name CLPS Chinese Name 胰辅脂酶抗体 Alias Colipase; Colipase pancreatic; Pancreatic colipase preproprotein; COL_RAT; COL_HUMAN. Research Area Tumour Cell biology immunology Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 10kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from rat CLPS: 41-112/112 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.
Subunit:
Forms a 1:1 stoichiometric complex with pancreatic lipase.
Subcellular Location:
Secreted.
Post-translational modifications:
Expressed by the pancreas.
Similarity:
Belongs to the colipase family.
SWISS:
P17084
Gene ID:
25680
Database links:Entrez Gene: 1208 Human
Omim: 120105 Human
SwissProt: P04118 Human
Unigene: 1340 Human
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