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Rabbit Anti-ROR1 antibody
Rabbit Anti-ROR1 antibody
ROR1_HUMAN; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; receptor tyrosine kinase like orphan receptor 1; dJ537F10.1;
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  • NO.:SL10076R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,(predicted: Rat,Dog,Pig,Cow,Rabbit,)
    Applications:WB ELISA
    concentration:1mg/ml
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Product Name ROR1
Chinese Name 非酪氨酸蛋白激酶跨膜受体ROR1抗体
Alias ROR1_HUMAN; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; receptor tyrosine kinase like orphan receptor 1; dJ537F10.1;  
Research Area Chromatin and nuclear signals  Neurobiology  Signal transduction  Kinases and Phosphatases  Cell differentiation  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
Applications WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 100kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human ROR1: 301-360/937 <Extracellular>
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Function:
Tyrosine-protein kinase receptor whose role is not yet clear.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Contains 1 FZ (frizzled) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 kringle domain.
Contains 1 protein kinase domain.

SWISS:
Q01973

Gene ID:
4919

Database links:

Entrez Gene: 4919 Human

Entrez Gene: 26563 Mouse

Entrez Gene: 362550 Rat

Omim: 602336 Human

SwissProt: Q01973 Human

SwissProt: Q9Z139 Mouse

Unigene: 654491 Human

Unigene: 391716 Mouse

Unigene: 57252 Mouse



Product Picture
Sample:
A549(Human) Cell Lysate at 30 ug
293T(Human) Cell Lysate at 30 ug
MDA-MB-231 (Human) Cell Lysate at 30 ug
Primary: Anti- ROR1 (SL10076R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 130 kD
Observed band size: 130 kD

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