Product Name	MUC13
Chinese Name	粘蛋白13抗体
Alias	MUC13 Down regulated in colon cancer 1; DRCC1; MUC 13; MUC-13; Mucin 13, cell surface associated; RECC; UNQ6194; MUC13_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MUC13: 175-270/511 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MUC13 is a mucin. These are secreted or transmembrane glycoproteins that are expressed mainly in the digestive tract and on epithelial surfaces. MUC13 is upregulated in gastric cancer. Mucins have also been implicated in inflammatory bowel diseases. Function: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Subunit: Homodimer of beta subunits. Subcellular Location: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Also exists as a soluble form. Tissue Specificity: Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach. Post-translational modifications: Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homo-oligomerization into dimers is dependent on intrachain disulfide bonds. Highly N-glycosylated. Similarity: Contains 3 EGF-like domains. Contains 1 SEA domain. SWISS: Q9H3R2 Gene ID: 56667 Database links: Entrez Gene: 56667 Human Omim: 612181 Human SwissProt: Q9H3R2 Human Unigene: 5940 Human
Product Picture	Sample:Kidney (Mouse)Lysate at 40 ug Primary: Anti- MUC13(SL10074R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 54kD Observed band size: 54kD Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MUC13) Polyclonal Antibody, Unconjugated (SL10074R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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