Product Name	VEGFB167
Chinese Name	血管内皮生长因子B167
Alias	VEGFB 167; VEGFB-167; Vascular endothelial growth factor B; VEGF B; VEGFB; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN.
Research Area	Tumour  Cell biology  Neurobiology  Growth factors and hormones  Kinases and Phosphatases  The cell membrane受体  vascular endothelial cell
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human VEGFB isoform VEGFB-167: 121-188/188
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1. Function: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Subcellular Location: Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin. Tissue Specificity: Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Post-translational modifications: VEGF-B167 is O-glycosylated. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P49765-2 Gene ID: 7423 Database links: Entrez Gene: 7423 Human Entrez Gene: 22340 Mouse Entrez Gene: 89811 Rat Omim: 601398 Human SwissProt: P49765 Human SwissProt: P49766 Mouse SwissProt: O35485 Rat Unigene: 78781 Human Unigene: 15607 Mouse Unigene: 198550 Rat
Product Picture	Sample: H9C2(Rat) Cell Lysate at 30 ug Primary: Anti-VEGFB167 (SL10071R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 21 kD

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