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Product Name Lymphotoxin Beta Chinese Name Tumour坏死因子C/淋巴毒素β抗体 Alias LT beta; LT-beta; LTB; lymphotoxin beta (TNF superfamily, member 3); lymphotoxin beta; lymphotoxin-beta; OTTHUMP00000038214; p33; TNF C; TNF-C; TNFC; TNFC_HUMAN; TNFSF3; tumor necrosis factor C (lymphotoxin beta); tumor necrosis factor C; tumor necrosis factor ligand superfamily member 3. Research Area Tumour immunology Signal transduction Growth factors and hormones cell factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Lymphotoxin Beta: 171-244/244 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex and this complex is the primary ligand for the lymphotoxin-beta receptor. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is probably non-functional. Alternative splicing results in multiple transcript variants encoding different isoforms.
Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Subunit:
Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.
Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).
Tissue Specificity:
Spleen and thymus.
Similarity:
Belongs to the tumor necrosis factor family.
SWISS:
Q06643
Gene ID:
4050
Database links:Entrez Gene: 4050 Human
Entrez Gene: 16994 Mouse
Omim: 600978 Human
SwissProt: Q06643 Human
SwissProt: P41155 Mouse
Unigene: 376208 Human
Unigene: 1715 Mouse
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