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Product Name REG4 Chinese Name 再生基因蛋白4抗体 Alias Gastrointestinal secretory protein; GISP; REG IV; REG like protein; Regenerating gene type IV; Regenerating islet derived family member 4; Regenerating islet derived protein 4 precursor; REGIV; RELP; REG4_HUMAN. literatures Specific References (2) | SL10036R has been referenced in 2 publications.[IF=5.13] Nishimura R et al. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J Gastroenterol. 2019 Jul;54(7):608-620. 3D IHC ; Human.[IF=2.489] Dandan Chai. et al. CDX2 and Reg IV expression and correlation in gastric cancer. Bmc Gastroenterol. 2021 Dec;21(1):1-12 IHC ; Human.Research Area Tumour Cell biology Chromatin and nuclear signals Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 18kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human REG4: 71-158/158 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Reg IV is part of the regenerating gene family within the C-type lectin superfamily. This family is involved in liver, pancreatic, gastric and intestinal cell proliferation and differentiation. Reg IV is a 158-amino acid secretory protein implicated in cell regeneration and/or survival with a definite growth stimulating effect on pancreatic beta cells. It is highly expressed in colorectal, gastric, prostate and other types of cancer. Reg IV-positive tumor cells display different phenotypes including mucus-secreting, enterocyte-like, and undifferentiated.
Function:
May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.
Similarity:
Contains 1 C-type lectin domain.
SWISS:
Q9BYZ8
Gene ID:
83998
Database links:Entrez Gene: 83998 Human
Omim: 609846 Human
SwissProt: Q9BYZ8 Human
Unigene: 660883 Human
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