Product Name	NCR1
Chinese Name	细胞毒性受体NK-p46抗体
Alias	Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.
literatures	Specific References  (3)     |     SL10027R has been referenced in 3 publications. [IF=6.43] Pan, Pan, et al. "Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer." Frontiers in Immunology 8 (2017): 997.  IHC-P ;  Mouse.   PubMed:28861089 [IF=1.83] VINDEVOGEL, EVA, et al. "The Use of Toll-like Receptor 4 Agonist to Reshape the Immune Signature in Ovarian Cancer." Anticancer Research36.11 (2016): 5781-5792.  IHC-P ;  Mouse.   PubMed:27793900 [IF=1.26] Jaime-Ramirez et al. Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma. (2017) Mol.Ther.Oncolytics. 5:87-96  IHC-P ;  Mouse.   PubMed:28812060
Research Area	Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD335: 198-206/304 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G Subcellular Location: Cell membrane. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Post-translational modifications: N-glycosylated. O-glycosylated. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: O76036 Gene ID: 9437 Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Entrez Gene: 117547 Rat Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse SwissProt: Q9Z0H5 Rat Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Spleen (Mouse) Lysate at 40 ug Lymph node (Mouse) Lysate at 40 ug A431(Human) Cell Lysate at 30 ug Raji(Human) Cell Lysate at 30 ug Primary: Anti- NCR1 (SL10027R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 46 kD Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Rat Lymph node tissue lysates Lane 4: Human HL-60 cell lysates Primary: Anti-NCR1 (SL10027R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kDa Observed band size: 48 kDa

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