Product Name	phospho-ZCWCC1 (Ser739)
Chinese Name	磷酸化ZCWCC1抗体
Alias	AC004542.C22.1.; p-MORC2(Ser739); phospho-ZCWCC1(Ser739); CW type with coiled coil domain 1; KIAA0852; ZCW3; ZCWCC1; Zinc finger; Zinc finger CW type coiled coil domain protein 1; Zinc finger CW type with coiled coil domain 1; Zing finger CW type 3 zinc finger CW-type coiled-coil domain protein 1; MORC family CW-type zine finger 2; MORC2.
literatures	Specific References  (1)     |     SL10016R has been referenced in 1 publications. [IF=5.17] Wang et al. PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis. (2015) Oncotarge. 6:9877-86  WB, IHC-P ;  Human, Mouse.   PubMed:25888627
Product Type	Phosphorylated anti
Research Area	Cell biology  transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	114kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human MORC2 around the phosphorylation site of Ser739: KR(p-S)VA
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The CW domain is a structural module found in many vertebrate, parasitic and plant proteins. It consists of a mononuclear four-cysteine zinc-finger domain that plays a role in DNA binding, chromatin methylation and early embryonic development. ZCWCC1 (zinc finger CW-type coiled-coil domain protein 1), also known as MORC2 (MORC family CW-type zinc finger protein 2) or ZCW3, is a 1,032 amino acid protein that contains one CW-type zinc finger domain. ZCWCC1 is located on chromosome 22 and is ubiquitously expressed with highest expression in pancreas, smooth muscle and testis. Expression of ZCWCC1 is upregulated in hypoxia, a pathological condition characterized by an inadequate supply of oxygen in the blood. Function: May act as a transcriptional repressor. Down-regulates CA9 expression. Subunit: Interacts with HDAC4. Subcellular Location: Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus. Tissue Specificity: Highly expressed in smooth muscle, pancreas and testis. Similarity: Contains 1 CW-type zinc finger. SWISS: Q9Y6X9 Gene ID: 22880 Database links: Entrez Gene: 22880 Human Entrez Gene: 74522 Mouse Entrez Gene: 289736 Rat SwissProt: Q9Y6X9 Human Unigene: 143840 Human Unigene: 555918 Human Unigene: 139127 Mouse
Product Picture	Sample: MCF-7(Human) Cell Lysate at 30 ug K562(Human) Cell Lysate at 30 ug Primary: Anti- phospho-ZCWCC1 (Ser739) (SL10016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Sample: MCF-7(Human) Cell Lysate at 30 ug K562(Human) Cell Lysate at 30 ug 293T(Human) Cell Lysate at 30 ug HepG2(Mouse) Cell Lysate at 30 ug Primary: Anti-phospho-ZCWCC1 (Ser739) (SL10016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti- phospho-ZCWCC1 (Ser739) (SL10016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Sample: U2os(Human) Cell Lysate at 30 ug Primary: Anti-phospho-ZCWCC1 (Ser739) (SL10016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Sample: 293T(Human) Cell Lysate at 30 ug HepG2(Human) Cell Lysate at 30 ug Primary: Anti- phospho-ZCWCC1 (Ser739) (SL10016R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 114 kD Observed band size: 114 kD Paraformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (phospho-ZCWCC1 (Ser739)) Polyclonal Antibody, Unconjugated (SL10016R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-phospho-ZCWCC1(Ser739) Polyclonal Antibody, Unconjugated(SL10016R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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