Product Name	CLDN1
Chinese Name	紧密连接蛋白1抗体
Alias	CLD1_HUMAN; Claudin-1; Claudin 1; Claudin1; CLD1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944; ILVASC;
literatures	Specific References  (10)     |     SL10008R has been referenced in 10 publications. [IF=13.352] Guangdong Bai. et al. Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function. ENVIRON INT. 2022 Dec;170:107579  IF ;  Pig.   PubMed:36265358 [IF=10.753] Guangdong Bai. et al. Perinatal exposure to high concentration glyphosate-based herbicides induces intestinal apoptosis by activating endoplasmic reticulum stress in offspring. SCI TOTAL ENVIRON. 2023 Mar;865:161223  IF ;  Pig.   PubMed:36584959 [IF=5.285] Wenjuan Xun. et al. Dietary emodin alleviates lipopolysaccharide-induced intestinal mucosal barrier injury by regulating gut microbiota in piglets. ANIM NUTR. 2023 May;:  WB ;  Pig.   PubMed:10.1016/j.aninu.2023.05.004 [IF=4.932] Wenjuan Xun. et al. Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat. Int Immunopharmacol. 2021 Oct;99:107989  WB ;  Pig.   PubMed:34303281 [IF=4.546] Kexin Wang. et al. Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury. TOXINS. 2022 May;14(5):337  WB ;  Bovine.   PubMed:35622584 [IF=4.546] Qing Li. et al. Fumonisin B1 Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells. Toxins. 2021 Dec;13(12):863  WB ;  Pig.   PubMed:34941701 [IF=4.146] Jian Kang. et al. Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/NLRP3 Inflammasome Pathway. TOXICS. 2022 Jun;10(6):285  WB ;  Mouse,Pig.   PubMed:10.3390/toxics10060285 [IF=3.247] D.L. Wu. et al. Dietary supplementation of free or two fat-coated sodium butyrate with varying release times on gastrointestinal development and tight junctions in preweaning Holstein calves. Anim Feed Sci Tech. 2022 Mar;285:115224  WB ;  Cow.   PubMed:10.1016/j.anifeedsci.2022.115224 [IF=2.914]   WB ;  Pig.   PubMed:32649964 [IF=2.914] Xiaoli Gao. et al. Effects of Clostridium perfringens beta2 toxin on apoptosis, inflammation, and barrier function of intestinal porcine epithelial cells. Microb Pathogenesis. 2020 Oct;147:104379  WB ;  Pig.   PubMed:32649964
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CLDN1: 31-130/211 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed, with highest levels in liver and kidney. Similarity: Belongs to the claudin family. SWISS: O95832 Gene ID: 9076 Database links: Entrez Gene: 9076 Human Entrez Gene: 12737 Mouse Entrez Gene: 65129 Rat SwissProt: O95832 Human SwissProt: O88551 Mouse SwissProt: P56745 Rat
Product Picture	Sample: liver (Mouse) Lysate at 40 ug Primary: Anti-Claudin 1 (SL10008R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 23 kD Observed band size: 23 kD

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