Product Name	Butyrylcholinesterase
Chinese Name	丁酰胆碱酯酶抗体
Alias	Acylcholine acylhydrolase; Choline esterase II; CHE1; Butyrylcholine esterase; Pseudocholinesterase; BchE; CHLE_HUMAN.
Research Area	Neurobiology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	66kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BCHE: 505-602/602
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]. Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Subunit: Homotetramer; disulfide-linked. Dimer of dimers. Subcellular Location: Secreted. Tissue Specificity: Detected in blood plasma (at protein level). Present in most cells except erythrocytes. DISEASE: Butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]: Metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the type-B carboxylesterase/lipase family. SWISS: P06276 Gene ID: 590 Database links: Entrez Gene: 590 Human Omim: 177400 Human SwissProt: P06276 Human Unigene: 420483 Human 丁酰胆碱酯酶Bche又称假性胆碱酯酶。该酶主要分布于脑白质（中脑，桥脑，延脑，纹状体及丘脑等脑干区域），也分布于Cardiovascular系统、呼吸系统、消化系统等组织及腺体中，专一性水解丁酰胆碱酯而发挥其生理功能。目前有用于老年痴呆AD病方面的的研究。 （脊椎动物体内有两种胆碱酯酶：乙酰胆碱酯酶AchE，又叫真性胆碱酯酶。该酶不仅存在于胆碱能神经，也存在于非但碱能神经及其他组织，如胎盘、红细胞等，专一水解Ach；在一种就是丁酰胆碱酯酶Bche）
Product Picture	Sample: Hela Cell Lysate at 30 ug Primary: Anti- BCHE(CT) (SL0987R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 66 kD Observed band size: 63 kD

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