Product Name	NKG2D
Chinese Name	NK细胞受体2D（CD314）抗体
Alias	NKG2-D type II integral membrane protein; KLRK1; natural killer cell group 2D; NKG2-D isoform b; Klrk1; Nkrp2; NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K; NK lectin-like receptor; CD314; CD 314; CD314 antigen; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; Klrk1; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D_HUMAN; NKLLR; NKR P2; Nkrp2.
literatures	Specific References  (10)     |     SL0938R has been referenced in 10 publications. [IF=15.304] Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635  WB, IF, FC ;  Mouse.   PubMed:10.1016/j.biomaterials.2022.121635 [IF=13.751] Young Min Chung. et al. Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3. J Immunother Cancer. 2021 Dec;9(12):e002772  IF ;  Mouse.   PubMed:34887262 [IF=6.166] Young Min Chung. et al. FOXO3-dependent suppression of PD-L1 promotes anticancer immune responses via activation of natural killer cells. Am J Cancer Res. 2022; 12(3): 1241–1263  IF,WB ;  Mouse.   PubMed:35411241 [IF=3.73] Ruck, Tobias, et al. "CD4+ NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation." PLOS ONE 8.11 (2013): e81455.  IHC-P ;  Human.   PubMed:24282598 [IF=3.558] Meng H et al. ZG16 regulates PD-L1 expression and promotes local immunity in colon cancerTransl Oncol.2021 Feb;14(2):101003.  IHC ;  Human.   PubMed:33360840 [IF=3.202] Long Y et al. Downregulation of MCT 4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma.Cancer Med. 2018 Sep;7(9):4690-4700.  IHC-P ;  Mouse.   PubMed:30051648 [IF=2.38] Mozer-Lisewska, Iwona, et al. "Detection and Significance of Cytotoxic Cell Subsets in Biopsies of HCV-Infected Human Livers." Archivum immunologiae et therapiae experimentalis (2013): 1-8.  Human.   PubMed:24232187 [IF=1.73] Onishi,Hideya, et al. "Random Migration Contributes to Cytotoxicity of Activated CD8+ T-Lymphocytes But Not NK cells." Anticancer Research 34.8 (2014): 3947-3956.  Mouse.   PubMed:25075016 [IF=1.664] Song et al. Synergistic anti-tumor effects of dasatinib and dendritic cell vaccine on metastatic breast cancer in a mouse model. (2018) Oncol.Lett. 15:6831-6838  IHC ;  mouse.   PubMed:29731862 [IF=1.664] Song N et al. Synergistic anti-tumor effects of dasatinib and dendritic cell vaccine onmetastatic breast cancer in a mouse model. Oncology Letters.2018.  IHC-P ;  Mouse.   PubMed:10.3892/ol.2018.8188
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2μg/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Detection molecular weight	31-35 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat NKG2D: 121-219/219 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] Function: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. Subunit: Homodimer. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs). Similarity: Contains 1 C-type lectin domain. SWISS: O70215 Gene ID: 24934 Database links: Entrez Gene: 100528032 Human Entrez Gene: 22914 Human Entrez Gene: 27007 Mouse Entrez Gene: 24934 Rat Omim: 611817 Human SwissProt: P26718 Human SwissProt: O54709 Mouse SwissProt: O70215 Rat Unigene: 387787 Human Unigene: 8217 Mouse Unigene: 14544 Rat NKG2-D出现在免疫细胞上表达的受体，NKG2D属C型凝集素家族Transmembrane protein，广泛表达在NK细胞、CD8+的αβT细胞和γδT细胞表面，可以提高NK细胞对Tumour细胞的杀伤活性。
Product Picture	Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti- NKG2D (SL0938R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kD Observed band size: 26 kD Blank control (blue line): Mouse thymus cells (blue). Primary Antibody (green line): Rabbit Anti-NKG2D antibody (SL0938R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were fixed with 70% methanol (Overnight at 4℃) . Cells stained with Primary Antibody for 30 min at room temperature. The cells were then incubated in 1 X PBS/2%BSA/10% goat serum to block non-specific protein-protein interactions followed by the antibody for 15 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control:SW480. Primary Antibody (green line): Rabbit Anti-NKG2D antibody (SL0938R) Dilution: 2ug/Test; Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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