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Product Name phospho-heterochromatin protein 1 (pTyr41) Chinese Name 异染色质蛋白1Phosphorylated anti(果蝇) Alias Antigen p25; Cbx 5; Cbx5 antibody Chromobox homolog 5 (Drosophila HP1 alpha); Chromobox homolog 5 (HP1 alpha homolog Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Chromobox protein homologue 5 ; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP 1; HP 1A; HP1 alpha homolog ; HP1A ; HP1Hs alpha; HP1Hs-alpha. Product Type Phosphorylated anti Research Area Cell biology immunology Chromatin and nuclear signals Insect Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Fruit Fly, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Form Liquid Concentration 1mg/ml immunogen KLH conjugated Synthesised phosphopeptide derived from human SLC7A11around the phosphorylation site of Ser481: VE(p-Y)YL Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.
SWISS:
P05205
Gene ID:
N/A
Database links:
GenBank: ACI96782.1
异染色质蛋白1(Heterochromatin protein 1 (HP1))一般认为是异染色质的维持者,异染色质是转录沉默的固缩DNA,常常与中心粒等区域有关。这种固缩的DNA被认为是转录因子无法接近的,但近期的Science上发表的两篇报道对这个观点提出了挑战。 这个新的研究提出HP1可能是异染色质活性调控的重要因子,在细胞生理活动中具有的重要功能。
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