Product Name	PDX1
Chinese Name	胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体
Alias	Glucose sensitive factor; Glucose-sensitive factor; GSF; IDX 1; IDX-1; IDX1; Insulin promoter factor 1; insulin promoter factor 1 homeodomain transcription factor; insulin upstream factor 1; IPF 1; IPF-1; IPF1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF 1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox 1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox P; PDX 1; PDX-1; PDX1_HUMAN; Somatostatin transactivating factor 1; Somatostatin-transactivating factor 1; STF 1; STF-1; STF1.
literatures	Specific References  (6)     |     SL0923R has been referenced in 6 publications. [IF=8.025] Bing Yang. et al. Polysaccharide from Hovenia dulcis (Guaizao) improves pancreatic injury and regulates liver glycometabolism to alleviate STZ-induced type 1 diabetes mellitus in rats. INT J BIOL MACROMOL. 2022 Jun;:  WB ;  Rat.   PubMed:35764168 [IF=5.29] Zheng, Liming, et al. "The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation." Scientific Reports 6 (2016): 37414.  IF(IHC-P) ;  Goat.   PubMed:27857213 [IF=4.546] Chi-Hao Tsaiet al. The Powdered Root of Eurycoma longifolia Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice. Nutrients . 2020 Jul 16;12(7):2111.  IHC ;  mouse.   PubMed:32708678 [IF=2.08] Jian, Ruo-Lei, et al. "Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells." Gene (2015).  WB ;  Mouse.   PubMed:25724395 [IF=1.64] Hefei, Wang, et al. "Morphological Characteristics and Identification of Islet‐like Cells Derived From Rat Adipose‐derived Stem Cells Cocultured with Pancreas Adult Stem Cells." Cell Biology International (2014).  Rat.   PubMed:25262665 [IF=0] Herawati L et al. Increased apoptosis, but not pancreatic duodenal homeobox-1 expression in pancreatic islets is associated with intermittent glucose loads in mice. Diabetes mellitus, 2019,21(6):497-505.  IHC ;  Mouse.   PubMed:DOI:10.14341/DM9437
Research Area	Cell biology  Neurobiology  Growth factors and hormones  transcriptional regulatory factor  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDX1: 188-284/284
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017] Function: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Subunit: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Subcellular Location: Nucleus. Tissue Specificity: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Post-translational modifications: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. DISEASE: Defects in PDX1 are a cause of pancreatic agenesis (PAC)[MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant. Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Similarity: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Contains 1 homeobox DNA-binding domain. SWISS: P52946 Gene ID: 3651 Database links: Entrez Gene: 538927 Cow Entrez Gene: 493994 Dog Entrez Gene: 3651 Human Entrez Gene: 18609 Mouse Entrez Gene: 29535 Rat Omim: 600733 Human SwissProt: P52945 Human SwissProt: P52946 Mouse SwissProt: P52947 Rat Unigene: 32938 Human Unigene: 389714 Mouse Unigene: 54603 Rat PDX1是一种同源框转录因子-即胰十二指肠同源异型盒基因，又称IPF-1(胰岛素促进因子)、IDX-1、IUF-1。 近年来，科学家们对PDX1从不同的角度进行了卓有成效的研究。有学者认为；PDX1是胰腺发育及胰岛素基因转录表达的关键性转录因子，即决定于胰腺前体细胞向B、A、D细胞的分化。 还有学者认为：PDX1对于肠内胚层背胰芽和腹胰芽的生长、分化起重要作用，早期胰腺表达的PDX-1对胰腺上皮的形成和分化是必需的。
Product Picture	Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PDX-1 Polyclonal Antibody, Unconjugated(SL0923R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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