Product Name	DEK
Chinese Name	DEK癌基因Binding protein
Alias	D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DNA binding; DEK_HUMAN; OTTHUMP00000039357; Protein DEK.
literatures	Specific References  (1)     |     SL0874R has been referenced in 1 publications. [IF=2.42] Yang, Y., Wu, M., Geng, Y., Liu, X., Yang, Y., Chen, X., ... & Xie, L. (2017). Roles of DEK in the endometrium of mice in early pregnancy. Gene.  WB, IHC-P ;  Mouse.   PubMed:29109007
Research Area	Chromatin and nuclear signals  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEK: 101-200/315
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The DEK gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA which then induces positive supercoils into closed circular DNA, and is also involved during mRNA processing in splice site selection. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. Function: Involved in chromatin organization. Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. Subcellular Location: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Tissue Specificity: Ubiquitous. Expressed at relatively high levels. Post-translational modifications: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. DISEASE: Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene. Similarity: Contains 1 SAP domain. SWISS: P35659 Gene ID: 7913 Database links: Entrez Gene: 7913 Human Entrez Gene: 110052 Mouse Entrez Gene: 306817 Rat Omim: 125264 Human SwissProt: P35659 Human SwissProt: Q7TNV0 Mouse SwissProt: Q6AXS3 Rat Unigene: 484813 Human Unigene: 131150 Mouse Unigene: 25099 Rat DEK癌基因Binding protein，主要参与DNA核转录。目前多用于白血病及急性髓系白血病的研究。

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