Product Name	IL-1 Beta
Chinese Name	白介素1β/IL-1β抗体
Alias	IL1B_HUMAN; Interleukin-1 beta; interleukin 1 beta; IL1F2; IL-1 beta; Catabolin; IL-1; IL1F2; IL1beta; IL1-BETA; IL-1beta; IL-1 Beta; IL-1β; IL1β; IL-1B; IL1B;  IL-1B; IL-1 ß; IL-1-ß; IL-1 ß;
literatures	Specific References  (188)     |     SL0812R has been referenced in 188 publications. [IF=32.086] Yingying Jin. et al. A Novel “Inside-Out” Intraocular Nanomedicine Delivery Mode for Nanomaterials Biological Effects Enhanced Choroidal Neovascularization Occlusion and Microenvironment Regulation. ADV MATER. 2022 Dec;:2209690  IF ;  Mouse.   PubMed:36527723 [IF=16.744] Lubin Zhou. et al. A self-pumping dressing with in situ modification of non-woven fabric for promoting diabetic wound healing. CHEM ENG J. 2022 Dec;:141108  IHC ;  Rat.   PubMed:10.1016/j.cej.2022.141108 [IF=15.304] Jinbo Li. et al. Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. BIOMATERIALS. 2022 Aug;287:121651  IF ;  Mouse.   PubMed:35777331 [IF=12.121] Haile Liu. et al. Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions. Nat Commun. 2021 Jan;12(1):1-14  IHC ;  Mouse.   PubMed:33414464 [IF=10.753] Panhong Wu. et al. Interleukin-17A knockout or self-recovery alleviated autoimmune reaction induced by fluoride in mouse testis. SCI TOTAL ENVIRON. 2023 Apr;:163616  WB ;  Mouse.   PubMed:37086998 [IF=10.383] Zhen Xu. et al. Green Biosynthesis of Silver Nanoparticles Using Aqueous Extracts of Ageratum Conyzoides and Their Anti-Inflammatory Effects. ACS APPL MATER INTER. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse,Human.   PubMed:36881383 [IF=10.317] Amlan Chakraborty. et al. Pulmonary myeloid cell uptake of biodegradable nanoparticles conjugated with an anti-fibrotic agent provides a novel strategy for treating chronic allergic airways disease. Biomaterials. 2021 Jun;273:120796  IHC ;  Mouse.   PubMed:33894403 [IF=9.58] Xiaoli Guo. et al. ASK1 signaling regulates phase-specific glial interactions during neuroinflammation. P Natl Acad Sci Usa. 2022 Feb;119(6):  IHC ;  Mouse.   PubMed:35101972 [IF=9.429] Wang, Daquan. et al. Protection of zero-valent iron nanoparticles against sepsis and septic heart failure. J NANOBIOTECHNOL. 2022 Dec;20(1):1-22  WB ;  Mouse.   PubMed:36064371 [IF=9.229] Jiarong Yang. et al. Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway. Acs Appl Mater Inter. 2022;14(3):3685–3700  WB ;  Mouse.   PubMed:35023338 [IF=9.038] Bing Han. et al. Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway. J Hazard Mater. 2021 May;:125984  WB ;  Mouse.   PubMed:34020360 [IF=8.943] Ze Kan. et al. Respiratory exposure to graphene oxide induces pulmonary fibrosis and organ damages in rats involving caspase-1/p38MAPK/TGF-β1 signaling pathways. CHEMOSPHERE. 2022 Jun;:135181  WB ;  Rat.   PubMed:35667501 [IF=8.943] Yujiao He. et al. Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway. CHEMOSPHERE. 2022 Nov;307:135662  WB ;  Mouse, Human.   PubMed:35830933 [IF=8.025] Lihui Ni. et al. The combination of insulin and linezolid ameliorates Staphylococcus aureus pneumonia in individuals with diabetes via the TLR2/MAPKs/NLRP3 pathway. INT J BIOL MACROMOL. 2023 Jul;242:124750  WB ;  Mouse.   PubMed:37160172 [IF=7.919] Chen Y et al. A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activityClin Transl Med.2020 Dec;10(8):e240.  WB、IHC ;  Mouse.   PubMed:33377656 [IF=7.658] Yongbo Kang. et al. Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability. Pharmacol Res. 2021 Dec;:106020  IHC ;  Mouse.   PubMed:34896249 [IF=7.62] Borgonetti, Vittoria. et al. Dual HDAC/BRD4 Inhibitors Relieves Neuropathic Pain by Attenuating Inflammatory Response in Microglia After Spared Nerve Injury. NEUROTHERAPEUTICS. 2022 May;:1-15  WB ;  Mouse.   PubMed:35501470 [IF=7.59] Xiaomeng Wang. et al. A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing. BIOMATER SCI-UK. 2022 Nov;:  IHC ;  Mouse.   PubMed:36426665 [IF=7.478] Ayaka Nakatani. et al. S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis. ALLERGOL INT. 2022 Sep;:  IHC ;  Human.   PubMed:36117020 [IF=7.397] Takamasa Kido. et al. Effectiveness of interleukin-4 administration or zinc supplementation in improving zinc deficiency-associated thymic atrophy and fatty degeneration and in normalizing T cell maturation process. 2022 Feb 09  IHC ;  Rat.   PubMed:35138640 [IF=7.324] Yongbo Kang. et al. A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway. MSYSTEMS. 2023 Feb 16  IHC ;  Mouse.   PubMed:36794950 [IF=7.086] Quan-Kuo He. et al. Captan exposure disrupts ovarian homeostasis and affects oocytes quality via mitochondrial dysfunction induced apoptosis. Chemosphere. 2022 Jan;286:131625  WB ;  Mouse.   PubMed:34303901 [IF=6.992] Qingyue Yang. et al. The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium. J Adv Res. 2021 Apr;:  WB ;  Rat.   PubMed:10.1016/j.jare.2021.04.002 [IF=6.922] Zhen-Ni Liu. et al. CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway. J Inflamm Res. 2022 Jan;15:53-70  IHC ;  Mouse.   PubMed:35023943 [IF=6.832] Yun Yu. et al. Geniposide promotes splenic Treg differentiation to alleviate colonic inflammation and intestinal barrier injury in ulcerative colitis mice. BIOENGINEERED. 2022;13(6):14616-14631  IHC ;  Mouse.   PubMed:36694912 [IF=6.633] Shuai Jiang. et al. Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury. BBA-MOL BASIS DIS. 2022 Sep;:166535  WB ;  Mouse.   PubMed:36058416 [IF=6.633] Zhi-Heng Zheng. et al. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behav Immun. 2021 Jan;91:505  WB ;  Mouse.   PubMed:33161163 [IF=6.604] Yuan Jiang. et al. Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis. Arterioscl Throm Vas. ;0:ATVBAHA.120.315525  WB ;  Mouse.   PubMed:33657879 [IF=6.576] Rong Li. et al. Integrated Analysis Reveals the Targets and Mechanisms in Immunosuppressive Effect of Mesalazine on Ulcerative Colitis. FRONT NUTR. 2022; 9: 867692  IHC,IF ;  Mouse.   PubMed:35662946 [IF=6.575] Qingqing Liu. et al. A Synbiotic Ameliorates Con A-Induced Autoimmune Hepatitis in Mice Through Modulation of Gut Microbiota And Immune Imbalance. MOL NUTR FOOD RES. 2023 Jan;:2200428  IF,IHC ;  Mouse.   PubMed:36708241
Research Area	Cell biology  immunology  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17/32kDa
Detection molecular weight	17/32 kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-1beta: 101-200/269
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Subunit: Monomer. Subcellular Location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Similarity: Belongs to the IL-1 family. SWISS: P01584 Gene ID: 3553 Database links: Entrez Gene: 3553 Human Entrez Gene: 16176 Mouse Entrez Gene: 24494 Rat Omim: 147720 Human SwissProt: P01584 Human SwissProt: P10749 Mouse SwissProt: Q63264 Rat Unigene: 126256 Human Unigene: 222830 Mouse Unigene: 9869 Rat Growth factors and hormones（ Growth Factor and Hormones） IL-1β是一种glycoprotein，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要做 用。 IL-1β前体在细胞内合成后被酶剪切为成熟形态后排出到细胞外,IL-1β的前体有153个氨基酸。成熟形态有116个氨基酸。
Product Picture	Sample: Lane 1: Normal Mouse Raw264.7 cell lysates Lane 2: Raw264.7 treated with 100ng/ml lipopolysaccharide (LPS) for 6h, then with 300ng/ml Brefeldin A added after 3 hours Primary: Anti-IL-1 Beta (SL0812R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17/32 kDa Observed band size: 35 kDa Tissue/cell: Human cervical carcinoma tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-1 Beta/IL-1B Polyclonal Antibody, Unconjugated(SL0812R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-1 Beta/IL-1B Polyclonal Antibody, Unconjugated(SL0812R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-1 Beta/IL-1B Polyclonal Antibody, Unconjugated(SL0812R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Blank control (black line): A431(black) (The cells were fixed with 2% paraformaldehyde (10 min) , then permeabilized with PBST for 30 min on room temperature) Primary Antibody (green line): Rabbit Anti-PTP1B antibody (SL3152R) ; Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC;Dilution: 1μg /test.

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