Product Name	CGRP-1/2
Chinese Name	降钙素基因相关肽1/2抗体
Alias	CGRP-I + CGRP-II; CGRP-1/2; Procalcitonin; Beta type CGRP; CALC2; CALCB; Calcitonin 1; Calcitonin 2; Calcitonin gene related peptide; Calcitonin gene related peptide II; Calcitonin related polypeptide beta; CGRP; CGRP II; CGRP2; CT; Calcitonin/calcitonin related polypeptide alpha; Katacalcin; MGC126648; CALCA_HUMAN; CALCB_HUMAN; Calcitonin gene-related peptide 2; Beta-type CGRP; Beta-CGRP; Calcitonin gene-related peptide II; CGRP-II; CGRP-I.
literatures	Specific References  (13)     |     SL0791R has been referenced in 13 publications. [IF=6.656] Yuxin Li. et al. Structure-based virtual screening for discovery of Paederosidic Acid from Paederia Scandens as novel P2Y14R antagonist. PHYTOMEDICINE. 2023 May;:154851  IF ;  Mouse.   PubMed:37149963 [IF=5.23] He, Qin-Qin, et al. "MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection." Scientific Reports 6 (2016).  IHC-P ;  Rat.   PubMed:27748416 [IF=3.874] Bo Liu. et al. Rapid FRET-based homogeneous immunoassay of procalcitonin using matched carbon dots labels. Nanotechnology. 2021 Dec;33(8):085702  immunosensor.   PubMed:34788745 [IF=3.448] Liu D et al. Effects of inhalation of sevoflurane at different concentrations on TRPV1 in airways of rats at different developmental stages. Life Sci. 2020 May 15;249:117472.  IHC ;  rat.   PubMed:32112870 [IF=3.411] Liu Dan. et al. RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway. Biomed Res Int. 2021;2021:9956078  IF ;  human.   PubMed:34541002 [IF=3.22] Li et al. The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells. (2009) Acta.Pharmacol.Sin. 30:576-81  WB ;  Human.   PubMed:19349965 [IF=2.94] Tu, Guihua, et al. "P2X< sub> 7 inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury." Brain research bulletin (2013).  Rat.   PubMed:23688519 [IF=2.63] Liu, Jun, et al. "Sensory–sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor." Purinergic Signalling (2013): 1-17.  Rat.   PubMed:23754120 [IF=2.014] Li LI. et al. The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats. Chin J Nat Medicines. 2020 May;18:356  IHC ;  Rat.   PubMed:10.1016/S1875-5364(20)30042-X [IF=1.892] Li CL et al. Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing. International Journal of Polymer Science.2019 9432194.  IHC-P&WB ;  Rat.   PubMed:doi:10.1155/2019/9432194 [IF=1.864] Yadong Yang. et al. Effects of highly selective sensory/motor nerve injury on bone metabolism and bone remodeling in rats.. J MUSCULOSKEL NEURON. 2022 Dec;22(4):524-535  ICC ;  Rat.   PubMed:36458390 [IF=0.78] Liu, Zhi-ming, et al. "Mutual Effect between Neuropeptides and Inflammatory Cytokines in Neurogenic SMSCs of Human Temporomandibular Joint." J Huazhong Univ Sci Technol [Med Sci] 34.4 (2014): 602-607.  WB ;  Human.   PubMed:25135735 [IF=0.18] Wang, Jianlong, et al. "Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates." Neural Regeneration Research 8.24 (2013): 2213.  IHC-P ;  Rat.   PubMed:25206531
Research Area	Cell biology  immunology  Neurobiology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	3.8/14kDa
Detection molecular weight	4/14-17 kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Calcitonin gene-related peptide 1: 65-130/130
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. Subcellular Location: Secreted. Similarity: Belongs to the calcitonin family. SWISS: P06881/P10092 Gene ID: 796/797 Database links: Entrez Gene: 796 Human Entrez Gene: 797 Human Entrez Gene: 116903 Mouse Entrez Gene: 12310 Mouse Entrez Gene: 171519 Rat Entrez Gene: 24241 Rat Omim: 114130 Human Omim: 114160 Human SwissProt: P06881 Human SwissProt: P10092 Human SwissProt: P70160 Mouse SwissProt: Q99JA0 Mouse SwissProt: P01256 Rat SwissProt: P01257 Rat Unigene: 37058 Human Unigene: 534305 Human Unigene: 273838 Mouse Unigene: 4361 Mouse Unigene: 88080 Rat Unigene: 90085 Rat CGRP活性多肽，有37个氨基酸组成，具有多种生理功能，其药理作用已受到广泛重视. CGRP （又称CGRP-1/2或CGRPa/β）广泛分布于神经系统的一种神经肽，在外周及脊髓参与伤害性信息的传递及痛敏化的形成，并与P物质、兴奋性氨基酸、辣椒素1型受体、Chemokine、激活素、大麻素受体、阿片受体、神经生长因子、血管活性肠肽、5-羟色胺、糖皮质激素等生物活性物质或受体在痛觉调制过程中存在相互影响。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CGRP) Polyclonal Antibody, Unconjugated (SL0791R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CGRP/CGRP2 Polyclonal Antibody, Unconjugated(SL0791R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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