Product Name	IL-8/CXCL8
Chinese Name	白介素8抗体
Alias	Interleukin-8; Interleukin 8; Interleukin8;(Ala-IL-8)77; (Ser-IL-8)72; 3 10C; 310C; AMCF 1; AMCF1; b ENAP; Bbeta thromboglobulin like protein; Beta thromboglobulin like protein; C-X-C motif chemokine 8; CXC chemokine ligand 8; CXCL 8; CXCL8; Emoctakin; GCP 1; GCP-1; GCP/IL-8 protein I; GCP/IL-8 protein II; GCP/IL-8 protein III; GCP/IL-8 protein IV; GCP/IL-8 protein V; GCP/IL-8 protein VI; GCP1; Granulocyte chemotactic protein 1; IL 8; IL-8; IL-8(1-77); IL-8(9-77); IL8; IL8/NAP1 form I; IL8/NAP1 form II; IL8/NAP1 form III; IL8/NAP1 form IV; IL8/NAP1 form V; IL8/NAP1 form VI; IL8_HUMAN; Inteleukin 8; Interleukin8; K 60; K60; LECT; LUCT; Lymphocyte derived neutrophil activating factor; Lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF; MDNCF-b; MDNCF-c; MONAP; Monocyte derived neutrophil activating peptide; Monocyte derived neutrophil activating protein; Monocyte derived neutrophil chemotactic factor; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; NAF; NAP 1; NAP-1; NAP1; Neutrophil activating factor; Neutrophil activating peptide 1; Neutrophil activating protein 1; Neutrophil-activating factor; Neutrophil-activating protein 1; Protein 3 10C; Protein 3-10C; SCYB 8; SCYB8; Small inducible cytokine subfamily B member 8; T cell chemotactic factor; T-cell chemotactic factor; TSG 1; TSG1.
literatures	Specific References  (20)     |     SL0780R has been referenced in 20 publications. [IF=12.771] Yuliani, Fara Silvia. et al. Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells. J BIOMED SCI. 2022 Dec;29(1):1-22  IHC, IF ;  Human.   PubMed:36369000 [IF=11.33] Zhang, Tao, et al. "CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment." Nature Communications 7 (2016).  IF(IHC-P) ;  Human.   PubMed:27241286 [IF=10.19] Xingliang Dai. et al. Crosstalk between microglia and neural stem cells influences the relapse of glioblastoma in GBM immunological microenvironment. CLIN IMMUNOL. 2023 Jun;251:109333  IHC ;  Human.   PubMed:37088298 [IF=7.129] Yu Xia. et al. Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition. ECOTOX ENVIRON SAFE. 2023 Jan;249:114364  WB ;  Mouse.   PubMed:36508806 [IF=5.738] Junfeng Qiu. et al. FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer. FRONT ONCOL. 2022; 12: 894043  WB, IHC ;  Human.   PubMed:35898871 [IF=5.23] Huang, Qi. "IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma." Scientific Reports 6 (2016).  IHC-P ;  Human.   PubMed:27819281 [IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856.  WB ;  Rabbit.   PubMed:22422340 [IF=5.195] Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626  IHC ;  Mouse.   PubMed:10.1016/j.jep.2022.115626 [IF=4.996] Ren, Xiaoli. et al. Expression and significance of IL-6 and IL-8 in canine mammary gland tumors. SCI REP-UK. 2023 Jan;13(1):1-9  IHC,WB ;  Dog.   PubMed:36693957 [IF=4.741] Chen Fanghua. et al. SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis. CARCINOGENESIS. 2023 Mar;:  IHC ;  Human.   PubMed:36857607 [IF=4.35] Xin Fan. et al. Anti-Colon Cancer Activity of Novel Peptides Isolated from In Vitro Digestion of Quinoa Protein in Caco-2 Cells. Foods. 2022 Jan;11(2):194  WB ;  Human.   PubMed:35053925 [IF=4.162] Mingsheng Lyu. et al. Molecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study. Drug Des Dev Ther. 2022; 16: 909–929  IHC,WB ;  Rat.   PubMed:35386850 [IF=3.992] Cittrarasu Vetrivel. et al. MoS2-ZnO Nanocomposite Mediated Immunosensor for Non-Invasive Electrochemical Detection of IL8 Oral Tumor Biomarker. DIAGNOSTICS. 2023 Jan;13(8):1464   PubMed:37189565 [IF=3.926] Pengyuan Kang. et al. Interleukin 8 in plasma is an efficacy marker for advanced non-small cell lung cancer treated with hypofractionated radiotherapy and PD-1 blockade. CYTOKINE. 2023 Mar;163:156133  IF ;  Human.   PubMed:36724715 [IF=3.895] Yang W et al. The Effect of Low and High Dose Deoxynivalenol on Intestinal Morphology, Distribution, and Expression of Inflammatory Cytokines of Weaning Rabbits. Toxins (Basel). 2019 Aug 13;11(8). pii: E473.  WB&IHC-P ;  Rabbit.   PubMed:31412640 [IF=3.86] Wu, Bo. et al. Diagnostic values of plasma matrix metalloproteinase-7, interleukin-8, and gamma-glutamyl transferase in biliary atresia. EUR J PEDIATR. 2022 Sep;:1-9  IF ;  Human.   PubMed:36094664 [IF=2.51] Lu, Yongping, et al. "Assessment of atherosclerotic plaques in the rabbit abdominal aorta with interleukin-8 monoclonal antibody-targeted ultrasound microbubbles." Molecular biology reports (2013): 1-10.  IHC-P ;  Rabbit.   PubMed:23292075 [IF=2.092] Ding S et al. Inflammatory cytokines tumor necrosis factor-α and interleukin-8 enhance airway smooth muscle contraction by increasing L-type Ca channel expression.(2018) Clin. Exp. Pharmacol. Physiol.Sep 10  Mouse.   PubMed:30203559 [IF=1.935] Verma S et al. Non-invasive oral cancer detection from saliva using zinc oxide–reduced graphene oxide nanocomposite based bioelectrode. MRS Communications,2019, 1–8.  Other ;   PubMed:doi:10.1557/mrc.2019.138 [IF=1.69] Xu et al. Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis. (2016) Mol.Med.Re. 13:4167-74  IHC ;  Rat.   PubMed:27035125
Research Area	Cell biology  immunology  Growth factors and hormones  Chemokine  Exchange protein  cell factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rabbit,  (predicted: Pig, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8/9kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-8: 31-99/99
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008] Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Subunit: Homodimer. Subcellular Location: Secreted. Post-translational modifications: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: P10145 Gene ID: 3576 Database links: Entrez Gene: 3576 Human Entrez Gene: 396880 Pig Omim: 146930 Human SwissProt: P10145 Human SwissProt: P26894 Pig Unigene: 624 Human 白介素-8
Product Picture	Tissue/cell: rabbit carotid artery; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-8/CXCL8 Polyclonal Antibody, Unconjugated(SL0780R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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