Product Name	SFTPA1
Chinese Name	肺表面活性蛋白A抗体
Alias	SP-A; SFTPA2; SFTPA1; Surfactant Protein A; pulmonary surfactant-associated glycoprotein A; Pulmonary surfactant-associated protein A2 precursor; SP-A1; SP-A2; SP-A; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; MGC133365; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein; SFTP1; SFTPA; SFTPA1B; SP A; SP A1; Surfactant pulmonary associated protein A1; PSPA; SPA2; SFTP1; SPAII; COLEC5; SFTPA2B; SFTA1_HUMAN; SFPA2_HUMAN; Pulmonary surfactant-associated protein A1; Pulmonary surfactant-associated protein A2.
literatures	Specific References  (3)     |     SL0770R has been referenced in 3 publications. [IF=3.061] Fang Q et al. pre-B cell colony enhancing factor negatively regulates Na and fluid transport in lung epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2047-2054. eCollection 2018.  ICF&WB ;  Rat.   PubMed:30093942 [IF=2.741] Tara Bocking. et al. Research article expression of surfactant protein-A and D, and CD9 in lungs of 1 and 30 day old foals. Bmc Vet Res. 2021 Dec;17(1):1-9  WB,IHC ;  Foal.   PubMed:34225699 [IF=0.267] Tai-Wen Raoet al. Effect of oxygen supplement during targeted temperature management on acute lung injury in the early stage of traumatic hemorrhagic shock. European Journal of Inflammation Volume 18: 1–7  WB ;  rabbit.   PubMed:10.1177/2058739220930448
Research Area	Tumour  Cell biology  immunology  Signal transduction  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SFTPA2/SFTPA1: 23-120/248
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009] Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Subunit: Oligomeric complex of 6 set of homotrimers. Subcellular Location: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. DISEASE: Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Similarity: Belongs to the SFTPA family. Contains 1 C-type lectin domain. Contains 1 collagen-like domain. SWISS: Q8IWL2 Gene ID: 653509 Database links: Entrez Gene: 610540 Dog Entrez Gene: 653509 Human Omim: 178630 Human SwissProt: P06908 Dog SwissProt: Q8IWL2 Human Unigene: 535295 Human 肺泡表面活性物质A（SP-A）属糖Binding protein家族,参与肺泡表面活性膜的形成和代谢,除在Ⅱ型细胞中强烈表达外，在细支气管、支气管上皮内也有灶性表达。
Product Picture	Formalin-fixed and paraffin embedded mouse lung tissue labeled Anti-SP-A Polyclonal Antibody, Unconjugated (SL0770R) at 1:2000, followed by conjugation to the secondary antibody and DAB staining Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SP-A Polyclonal Antibody, Unconjugated(SL0770R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SP-A Polyclonal Antibody, Unconjugated(SL0770R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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