Product Name	PAP2c
Chinese Name	磷脂酸磷酸酶2C抗体
Alias	PPAP2C; EC 3.1.3.4; Phosphatidic acid phosphatase 2c; Lipid phosphate phosphohydrolase 2; LPP2; PAP 2c; PAP2 G; PAP2 gamma; Phosphatidic acid phosphatase 2c; Phosphatidic acid phosphatase type 2C; Phosphatidate phosphohydrolase type 2c; Type 2 phosphatidic acid phosphatase gamma; PAP2c; PAP-2c; PAP2G; PAP2-gamma; LPP2_HUMAN; PAP2-G.
Research Area	Tumour  Cell biology  Signal transduction  Kinases and Phosphatases  Lipoprotein  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PAP2c: 81-276/288
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Subunit: Homodimer. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Found mainly in brain, pancreas and placenta. Similarity: Belongs to the PA-phosphatase related phosphoesterase family. SWISS: O43688 Gene ID: 8612 Database links: Entrez Gene: 8612 Human Omim: 607126 Human SwissProt: O43688 Human PAP2c-磷脂酸磷酸酶-2C 又称：PAP2-gamma、PAP2-G主要用于胰岛素、糖及脂肪代谢方面的研究。

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