Product Name	KGF
Chinese Name	纤维母细胞生长因子7抗体
Alias	FGF 7; FGF7; FGF-7; Fibroblast Growth Factor 7;HBGF 7; HBGF7; HBGF-7; Keratinocyte growth factor precursor; Heparin binding growth factor 7; Keratinocyte Growth Factor; FGF7_HUMAN; Heparin-binding growth factor 7.
literatures	Specific References  (6)     |     SL0734R has been referenced in 6 publications. [IF=5.572] Haoming Chen. et al. Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells. FOOD CHEM TOXICOL. 2023 May;175:113694  WB,IHC ;  Mouse,Human.   PubMed:36868510 [IF=3.23] Cai, Yujiao, et al. "Keratinocyte growth factor improves epithelial structure and function in a mouse model of intestinal ischemia/reperfusion." PloS one7.9 (2012).  WB ;  Mouse.   PubMed:23028616 [IF=2.502] Pu J et al. FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063.  WB ;  Mouse.   PubMed:31555794 [IF=1.89] Cai, Yu-Jiao, et al. "Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo." Int J Clin Exp Pathol 5.6 (2012): 569-580.  WB ;  Mouse.   PubMed:22949940 [IF=1.07] Tang, Xiujun, et al. "The influences of adipose-derived stem cells (ASCs) on epithelial-mesenchymal cross-talk factors in the early stage of scar formation." Int J Clin Exp Med 10.1 (2017): 266-275.  IHC-P ;  Rabbit.   PubMed:ISSN:1940-5901/IJCEM0038319 [IF=0.13] Durak, Hatice, et al. "Effect of Mitomycin C on bFGF, TGF-β1, KGF-1 Expressions after Myringotomy: An Animal Study." J Int Adv Otol 11.3 (2015): 188-91.  IHC-P ;  Rat.   PubMed:26915147
Research Area	Tumour  immunology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	18kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KGF: 101-194/194
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Subunit: Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Subcellular Location: Secreted. Tissue Specificity: Epithelial cell. Similarity: Belongs to the heparin-binding growth factors family. SWISS: P21781 Gene ID: 2252 Database links: Entrez Gene: 2252 Human Entrez Gene: 14178 Mouse Entrez Gene: 29348 Rat Omim: 148180 Human SwissProt: P21781 Human SwissProt: P36363 Mouse SwissProt: Q02195 Rat Unigene: 567268 Human Unigene: 330557 Mouse Unigene: 98842 Rat KGF/FGF7 (Fibroblast growth factor 7) 又称：HBGF-7 纤维母细胞生长因子7，是FGF家族的主要成员之一。 FGF家族参与细胞生长、组织修复、胚胎生长发育、组织器官的形成、Tumour的生长和侵润等诸多生理病理功能。 成纤维细胞生长因子7的促增生作用主要来源于角化epithelial cells而不是间质细胞和endothelial cells，因此人们又称之为：角化epithelial cells生长因子（KGF）。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KGF) Polyclonal Antibody, Unconjugated (SL0734R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-KGF/FGF7 Polyclonal Antibody, Unconjugated(SL0734R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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