Product Name	Angiopoietin 2
Chinese Name	血管生成素2抗体
Alias	AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand; ANGP2_HUMAN.
literatures	Specific References  (6)     |     SL0677R has been referenced in 6 publications. [IF=6.68] Do HS et al. Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells. EBioMedicine. 2020 Jan 22;52:102633.  IHC-P ;  Human.   PubMed:31981984 [IF=3.149] Yuksel Olgun. et al. The Effect of Bevacizumab and Propranolol on Nasal Polyposis. INT J CLIN PRACT. 2022 Oct 12;2022:6174664  IHC ;  Human.   PubMed:36304979 [IF=3.072] Xue Y et al. miR‐205‐5p inhibits psoriasis‐associated proliferation and angiogenesis: Wnt/β‐catenin and mitogen‐activated protein kinase signaling pathway are involved. J Dermatol . 2020 Aug;47(8):882-892.  WB ;  Mouse&Human.   PubMed:32525225 [IF=2.84] Zhao, Qiuchen, et al. "Intranasal administration of Human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke." Brain Research (2015).  WB ;  Rat.   PubMed:26279113 [IF=2.14] Lv, Ming-ming, Xin-dong Fan, and Li-xin Su. "Is a Swine Model of Arteriovenous Malformation Suitable for Human Extracranial Arteriovenous Malformation? A Preliminary Study." Cardiovascular and interventional radiology (2013): 1-7.  IHC-P ;   PubMed:23652418 [IF=0] Du, Weiyan, et al. "The Expression and Significance of Angiopoietin-2 and Glucose Regulated Protein78 in Colorectal Cancer." Cancer Cell Research (2016).  IHC-P ;  Human.   PubMed:CancerCellResearch.9(2016)219-222
Research Area	Tumour  Cardiovascular  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Angiopoietin 2: 401-496/496
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. Subcellular Location: Secreted. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: O15123 Gene ID: 285 Database links: Entrez Gene: 285 Human Entrez Gene: 11601 Mouse Entrez Gene: 89805 Rat Omim: 601922 Human SwissProt: O15123 Human SwissProt: O35608 Mouse SwissProt: O35462 Rat Unigene: 583870 Human Unigene: 439874 Mouse Unigene: 138360 Rat 血管生成素2(angiopoietin-2, Ang-2)是Ang家族的成员之一,是特异性血管生成刺激因子,也是恶性Tumour早期的标志分子.
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-Angiopoietin 2 (SL0677R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 53 kD Observed band size: 53 kD Tissue/cell: human colon cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Ang2 Polyclonal Antibody, Unconjugated(SL0677R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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