Product Name	Connexin-45
Chinese Name	间隙连接蛋白45抗体
Alias	Connexin 45; Connexin45; Connexin-45; CX 31.9; CX 45; CX31.9; CX45; DKFZp686P0738; Gap junction alpha 7 protein; Gap junction alpha-7 protein; Gap junction protein alpha 7 45kDa; Gap junction protein alpha 7; Gap junction protein, gamma 1, 45kDa; GJA 7; GJA7; GJD3; Gap junction gamma-1 protein; CXG1_HUMAN.
Research Area	Cardiovascular  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Connexin-45: 81-130/396
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Subunit: A connexon is composed of a hexamer of connexins. Interacts with CNST. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Similarity: Belongs to the connexin family. Gamma-type subfamily. SWISS: P36383 Gene ID: 10052 Database links: Entrez Gene: 10052 Human Entrez Gene: 14615 Mouse Entrez Gene: 266706 Rat Omim: 608655 Human SwissProt: P36383 Human SwissProt: P28229 Mouse SwissProt: A4GVD1 Pig SwissProt: A4GG66 Rat Unigene: 195419 Rat Channel protein（Channel Protein） Connexin45又称缝隙连接膜Channel proteinalpha7，Cx45构成细胞间的通道,小分子成份可以借此在细胞间扩散。 Connexin-45是心肌缝隙连接蛋白的主要蛋白之一。

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