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Product Name PTP4A2 Chinese Name 肝再生磷酸酯酶2抗体 Alias Protein tyrosine phosphatase type IV A protein 2; Protein-tyrosinephosphatase 4a2; Protein-tyrosine phosphatase of regeneratingliver 2; PRL-2; PRL2; PRL 2; TP4A2_HUMAN; BM 008; EC 3.1.3.48; HH 13; HH13; HH7 2; HU PP 1; HUPP 1; HUPP1; OV 1; OV1; phosphatase of regenerating liver 2; Protein tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA; protein tyrosine phosphatase IVA2; Protein tyrosine phosphatase of regenerating liver 2; protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase type IVA member 2 isoform 1; protein tyrosine phosphatase type IVA, member 2; PTP (CAAXII); ptp IV1a; ptp IV1b; PTP4A; PTPCAAX2. 促肝细胞再生磷酸酶 Research Area Tumour Cell biology Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 19kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PTP4A2: 61-167/167 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Subunit:
In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.
Subcellular Location:
Cell membrane. Early endosome. Cytoplasm.
Tissue Specificity:
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.
Post-translational modifications:
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.
Similarity:
Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
Q12974
Gene ID:
8073
Database links:Entrez Gene: 8073 Human
Entrez Gene: 19244 Mouse
Omim: 601584 Human
SwissProt: Q12974 Human
SwissProt: O70274 Mouse
Unigene: 470477 Human
Unigene: 193688 Mouse
Unigene: 167750 Rat
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