Product Name	Slco1a1
Chinese Name	溶质载体有机阴离子Transporter家族成员1A1抗体
Alias	OATP-1; Organic anion-transporting polypeptide 1; SO1A1_RAT; Sodium-independent organic anion transporter 1; Solute carrier family 21 member 1; Solute carrier organic anion transporter family member 1A1.
literatures	Specific References  (5)     |     SL0607R has been referenced in 5 publications. [IF=6.876] Song Guochao. et al. Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. CLIN SCI. 2023 Apr;137(7):561-577  WB ;  Mouse.   PubMed:36795945 [IF=5.23] Enoki, Yuki, et al. "Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1." Scientific Reports 6 (2016): 32084.  WB ;  Mouse.   PubMed:27549031 [IF=3.3] Xu C, Zhu L, Chan T, Lu X, Shen W, et al. (2015) The Altered Renal and Hepatic Expression of Solute Carrier Transporters (SLCs) in Type 1 Diabetic Mice. PLoS ONE 10(3): e0120760.  WB ;  Mouse.   PubMed:25789863 [IF=2.76] Zhu, Liran, et al. "Saponins extracted from Dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats." Biomedicine & Pharmacotherapy 93 (2017): 88-94.  IHC-P ;  Rat.   PubMed:28624426 [IF=1.585] Pang et al. Gypenosides Inhibits Xanthine Oxidoreductase and Ameliorates Urate Excretion in Hyperuricemic Rats Induced by High Cholesterol and High Fat Food (Lipid Emulsion). (2017) Med.Sci.Monit. 23:1129-1140  IHC-P ;  Rat.   PubMed:28258276
Research Area	Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	74kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat Slco1a1: 2-90/670 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	mediates the transport of sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes Function: Mediates the Na(+)-independent transport of organic anions such as bromosulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Subunit: Binds to PDZK1. Interaction with PDZK1 is required for expression on hepatocyte surface. Subcellular Location: Basolateral cell membrane Tissue Specificity: Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon. Post-translational modifications: Glycosylated. Similarity: Belongs to the organo anion transporter (TC 2.A.60) family. [SIMILARITY] Contains 1 Kazal-like domain. SWISS: P46720 Gene ID: 50572 Database links: Entrez Gene: 28248 Mouse Entrez Gene: 50572 Rat SwissProt: Q9QXZ6 Mouse SwissProt: P46720 Rat Unigene: 231253 Rat
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-Slco1a1 (SL0607R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 74 kD Observed band size: 73 kD Tissue/cell: mouse kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-OATP-1/Slco1a1 Polyclonal Antibody, Unconjugated(SL0607R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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