Product Name	Cyclooxygenase 1
Chinese Name	前列腺素氧化环化酶1抗体
Alias	Cyclooxygenase-1; COX-1; COX 1; COX1; Cyclooxygenase1; Prostaglandin-endoperoxide synthase-1; prostaglandin-endoperoxide synthase 1; PTGS-1; Prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1 isoform 1 precursor; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; PGH1_HUMAN; PTGS1; Prostaglandin G/H synthase 1 precursor.
literatures	Specific References  (4)     |     SL0582R has been referenced in 4 publications. [IF=2.86] Li, Wei, et al. "Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo." International journal of molecular sciences 12.1 (2011): 668-681  WB ;  Mouse.   PubMed:21340007 [IF=2.38] Hu, Ruiqi, et al. "The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)." Prostaglandins & Other Lipid Mediators (2016).  IHC-P ;  Others.   PubMed:27246901 [IF=2.253] Chen Z et al. Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus). Prostaglandins and Other Lipid Mediators 148 (2020) 106412.  IHC-P ;  squirrel.   PubMed:doi:10.1016/j.prostaglandins.2020.106412 [IF=2.253] Wang Y et al. Seasonal expressions of COX-1, COX-2 and EP4 in the uteri of the wild Daurian ground squirrels (Spermophilus dauricus). Prostaglandins Other Lipid Mediat. 2019 Aug;143:106343.  IHC&WB ;  squirrel.   PubMed:31195125
Research Area	Tumour  Cardiovascular  immunology  Signal transduction  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cyclooxygenase 1: 151-250/599
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]. Function: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Subunit: Homodimer. Subcellular Location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Similarity: Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain. SWISS: Q63921 Gene ID: 5742 Database links: Entrez Gene: 5742 Human Entrez Gene: 19224 Mouse Entrez Gene: 24693 Rat Omim: 176805 Human SwissProt: P23219 Human SwissProt: P22437 Mouse SwissProt: Q63921 Rat Unigene: 201978 Human Unigene: 275434 Mouse Unigene: 44404 Rat Synthesis and Degradation（Synthesis and Degradation） COX1 前列腺素氧化环化酶-是前列腺素合成的关键酶之一，为诱导性酶，他参与细胞对生长因子、Tumour促进因子和cell factor的反应，这些因子均能诱导COX1表达，它也参与前列腺素的合成。
Product Picture	Sample: NIH/3T3(Mouse) Cell Lysate at 30 ug A431(Human) Cell Lysate at 30 ug Hela(Human) Cell Lysate at 30 ug Huvec(Human) Cell Lysate at 30 ug Primary: Anti-Cyclooxygenase 1 (SL0582R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63 kD Observed band size: 63 kD Tissue/cell: human laryngo carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-COX-1 Polyclonal Antibody, Unconjugated(SL0582R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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