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Product Name HAI-1 Chinese Name 肝细胞生长因子激活物抑制剂/HGFA Inhibitor 1抗体 Alias Hepatocyte Growth Factor Activator Inhibitor 1; Spint1; Hai1; HGFA Inhibitor 1; HAI-1; SPIT1_HUMAN. Research Area Tumour immunology Kinases and Phosphatases The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 55kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HAI-1: 451-529/529 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.
Function:
Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
Subunit:
Interacts with HGFAC.
Subcellular Location:
Secreted.
Similarity:
Contains 2 BPTI/Kunitz inhibitor domains.
Contains 1 LDL-receptor class A domain.
Contains 1 MANSC domain.
SWISS:
O43278
Gene ID:
6692
Database links:Entrez Gene: 6692 Human
Omim: 605123 Human
SwissProt: O43278 Human
Unigene: 233950 Human
HAI-1 是一种含两个 Kunitz 域的Transmembrane protein,可抑制由The cell membrane分泌的并且以游离形式存在的 HGFA 。 HAI-1 也可以作用于其它丝氨酸蛋白酶.
HAI-1 主要在胎盘、肾、胰腺、前列腺和小肠,也有报道称 HAI-1 会在肝癌中表达。Product Picture
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