Product Name	Matriptase
Chinese Name	蛋白裂解酶（一种新的癌基因）抗体
Alias	transmembrane protease, serine 6; 1300008A22Rik; IRIDA; MATRIPTASE2; TMPRSS6.
literatures	Specific References  (1)     |     SL0531R has been referenced in 1 publications. [IF=2.608] Kim S et al. Capsaicin induces atopic dermatitis-like manifestations through dysregulation of proteolytic system and alteration of filaggrin processing in rats. Exp Dermatol. 2018 Apr;27(4):332-339.  WB ;  Rat.   PubMed:29509988
Research Area	Tumour  Cell biology  Kinases and Phosphatases  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Matriptase: 11-100/855 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. Subunit: Interacts with CDCP1. May interact with TMEFF1. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Similarity: Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains. Contains 1 peptidase S1 domain. SWISS: Q9Y5Y6 Gene ID: 164656 Database links: Entrez Gene: 164656 Human Entrez Gene: 71753 Mouse Entrez Gene: 315388 Rat Omim: 609862 Human SwissProt: Q8IU80 Human SwissProt: Q9DBI0 Mouse Unigene: 370885 Human Unigene: 34056 Mouse Unigene: 214123 Rat 蛋白裂解酶是第一种已在分子水平上辨明的、与癌症相关的跨膜丝氨酸蛋白酶。他们的研究首次发现蛋白裂解酶可以诱发Tumour。蛋白裂解酶是一种The cell membrane蛋白，一直以来研究者们对这种蛋白裂解酶的致癌功能表示怀疑。 matriptase在多种上皮来源的Tumour中均高水平表达，有学者认为：matriptase作为一种癌基因，为Transmembrane protein而且位于细胞表面，部分位于胞浆。
Product Picture	Sample: Jurkat (Human) CellLysate at 40 ug Primary: Anti-Matriptase (SL0531R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 94 kD Observed band size: 125 kD HepG2 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (Matriptase) polyclonal Antibody, Unconjugated (SL0531R) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

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