Product Name	CD31
Chinese Name	血小板endothelial cells黏附分子-1抗体
Alias	platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule.
literatures	Specific References  (30)     |     SL0468R has been referenced in 30 publications. [IF=14.957] Pei-Ling Hsu. et al. Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. SCI ADV. 2023 Apr;9(15)  IF ;  Mouse,Human.   PubMed:37043564 [IF=11.508] Qinyu Ma. et al. Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling. Bone Res. 2021 Jan;9(1):1-12  IF,IHC ;  Mouse.   PubMed:33431863 [IF=11.467] Hidenori Ando. et al. Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment. J CONTROL RELEASE. 2022 Oct;350:414  IF ;  Mouse.   PubMed:35988781 [IF=10.317] Qi Sun. et al. Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers. Biomaterials. 2021 Feb;269:120648  IHC ;  Mouse.   PubMed:10.1016/j.biomaterials.2020.120648 [IF=8.65] Chen, Xiang, et al. "A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma." Cancer research 66.23 (2006): 11323-11330.  Mouse.   PubMed:17145878 [IF=6.583] Ahmad S et al. C3a Receptor Antagonist Therapy is Protective with or without Thrombolysis in Murine Thromboembolic Stroke. Br J Pharmacol. 2020 Jan 24.  FCM ;  Mouse.   PubMed:31975437 [IF=6.092]   IF ;  mouse.   PubMed:32786521 [IF=5.923] Jiaqiang Deng. et al. Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway. Int J Mol Sci. 2021 Jan;22(21):11356  FC ;  Dog.   PubMed:34768788 [IF=5.47] Guo, Yansu, et al. "A single injection of recombinant adeno-associated virus into the lumbar cistern delivers transgene expression throughout the whole spinal cord." Molecular Neurobiology (2015): 1-14.  IHC ;  Mouse.   PubMed:26050084 [IF=5.116] Mengna Duan. et al. Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing. Stem Cell Res Ther. 2020 Dec;11(1):1-11  IHC ;  Rat.   PubMed:33097078 [IF=4.831] Yu-Che Cheng. et al. Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis. Aging-Us. 2020 Sep 15; 12(17): 16803–16819  IHC ;  Mouse.   PubMed:32756007 [IF=4.61] Yue H et al. Gestational exposure to PM2.5 impairs vascularization of the placenta. Sci Total Environ. 2019 May 15;665:153-161.  IHC-P&WB ;  Mouse.   PubMed:30772544 [IF=4.064] Jingjing Zhao. et al. Bone Regeneration and Angiogenesis by Co-transplantation of Angiotensin II–Pretreated Mesenchymal Stem Cells and Endothelial Cells in Early Steroid-Induced Osteonecrosis of the Femoral Head:. Cell Transplant. 2022;():  IF ;  Rabbit.   PubMed:35313737 [IF=3.923] Sha Y et al. MGF E peptide improves anterior cruciate ligament repair by inhibiting hypoxia‐induced cell apoptosis and accelerating angiogenesis.(2018) J Cell Physiol. 2018 Oct 14.  IF ;  Rabbit.   PubMed:30317597 [IF=3.87] Ma, Yan, et al. "Intraocular expression of serum amyloid a and interleukin-6 in proliferative diabetic retinopathy." American journal of ophthalmology 152.4 (2011): 678-685.  IHC-F ;  Mouse.   PubMed:21704966 [IF=3.73] Zeng, Wei-qun, et al. "A New Method to Isolate and Culture Rat Kupffer Cells." PLOS ONE 8.8 (2013): e70832.  Rat.   PubMed:23967115 [IF=3.644] Kong Hyun Sun. et al. Antifreeze Protein Supplementation During the Warming of Vitrified Bovine Ovarian Tissue Can Improve the Ovarian Tissue Quality After Xenotransplantation. Front Endocrinol. 2021 May;12:627  IHC ;  Mouse.   PubMed:34122348 [IF=3.448] Tao B et al. Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy.J. Mater. Chem. B, 2019, DOI: 10.1039/C8TB03272F.  IHC-P ;  Mouse.   PubMed:DOI:10.1039/C8TB03272F [IF=3.297] Sheng Cao. et al. Ultrasound-targeted microbubble destruction-mediated Ang1 gene transfection improves left ventricular structural and sympathetic nerve remodeling in canines with myocardial infarction. Ann Transl Med. 2021 Feb; 9(3): 221  IHC ;  Dog.   PubMed:33708848 [IF=3.267] Joung-Hee Kim. et al. Mealworm Oil (MWO) Enhances Wound Healing Potential through the Activation of Fibroblast and Endothelial Cells. Molecules. 2021 Jan;26(4):779  IHC ;  Rat.   PubMed:33546205 [IF=3.22] Long, Connor, et al. "Isolation and characterization of canine placenta‐derived mesenchymal stromal cells for the treatment of neurological disorders in dogs." Cytometry Part A (2017).  FCM ;  Dog.   PubMed:28715613 [IF=3.04] Korkmaz, H. Ibrahim, et al. "Neutrophil Extracellular Traps Coincide with a Pro‐coagulant Status of Microcirculatory Endothelium in Burn Wounds." Wound Repair and Regeneration (2017).  IHC-P ;  Pig.   PubMed:28727215 [IF=2.824] Li W et al. Increased Angiogenic and Adipogenic Differentiation Potentials in Adipose-Derived Stromal Cells from Thigh Subcutaneous Adipose Depots Compared with Cells.(2018) Aesthet Surg J.  IF ;  Human.   PubMed:30358810 [IF=2.74] Norihiro Muroi. et al. Effects of long-term plate fixation with different fixation modes on the radial cortical bone in dogs. Plos One. 2021 Feb;16(2):e0247410  IHC ;  Dog.   PubMed:33606794 [IF=2.57] Vuletic, Ivan, et al. "Validation of Bevacizumab Therapy Effect on Colon Cancer Subtypes by Using Whole Body Imaging in Mice." Molecular Imaging and Biology: 1-10.  IHC-F ;  Mouse.   PubMed:28315202 [IF=2.56] Yuan, Qiao-ying, et al. "A targeted high-efficiency angiogenesis strategy as therapy for myocardial infarction." Life Sciences (2012).  IHC-P ;   PubMed:22469972 [IF=2.45] Yuan, Qiao-Ying, et al. "A visible, targeted high-efficiency gene delivery and transfection strategy." BMC biotechnology 11.1 (2011): 56.  IHC-P ;  Dog.   PubMed:21600027 [IF=1.539] Lin Chih-Hsun. et al. Frozen Fat Grafts Maintain Vascular Endothelial Growth Factor Expression and Mediate Angiogenesis During Adipose-Derived Stem Cell Enrichment for Soft Tissue Augmentation. 2022 Mar 01  IHC ;  Mouse.   PubMed:35102020 [IF=1.37] Zhang, Jun, et al. "Cardiac stem cells differentiate into sinus node-like cells." The Tohoku Journal of Experimental Medicine 222.2 (2010): 113-120.  Dog.   PubMed:20877167 [IF=1.076] Rossmeisl et al. Pathology of non-thermal irreversible electroporation (N-TIRE)-induced ablation of the canine brain. (2013) J.Vet.Sc. 14:433-40  IHC-P ;  Dog.   PubMed:23820168
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  Stem cells  Cell adhesion molecule  Cell Surface Molecule  glycoprotein  lymphocyte  t-lymphocyte  marrow cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Dog, Pig,  (predicted: Mouse, Rat, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	78kDa
Detection molecular weight	130 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD31: 601-680/738
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] Function: Induces susceptibility to atherosclerosis. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Subunit: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Subcellular Location: Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Tissue Specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines (at protein level). Post-translational modifications: Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P16284 Gene ID: 5175 Database links: Entrez Gene: 5175 Human Entrez Gene: 18613 Mouse Omim: 173445 Human SwissProt: P16284 Human SwissProt: Q08481 Mouse Unigene: 376675 Human Unigene: 514412 Human Unigene: 343951 Mouse 细胞粘附蛋白（Call Adhesion Protein） 血小板endothelial cells黏附分子-1 在血小板、endothelial cells、单核细胞、嗜中性细胞及某些T细胞亚群上表达的质膜glycoprotein。 属于免疫球蛋白超基因家族成员，在细胞外结构域中有6个C2亚类免疫球蛋白样保守性同原单位。在炎症应答中起作用。
Product Picture	Sample: Huvec(Human) Cell Lysate at 30 ug Primary: Anti-CD31 (SL0468R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78 kD Observed band size: 140 kD Cell:R.spleen Concentration:1:100 Host/Isotype:Rabbit/IgG Flow cytometric analysis of Rabbit IgG isotype control (Cat#: SL0468R) on R.spleen(green) compared with control in the absence of primary antibody (blue) followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG(H+L) secondary antibody .

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