Product Name	FOXE1
Chinese Name	甲状腺转录因子-2抗体
Alias	FKH L15; FKHL 15; FKHL15; Forkhead (Drosophila) like 15; forkhead (Drosophila)-like 15; forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead drosophila homolog like 15; Forkhead like 15; Forkhead related protein FKHL 15; Forkhead related protein FKHL15; FOX E1; FOX E2; FOXE 1; FOXE 2; FOXE-2; FOXE1; FOXE2; HFKH 4; HFKH4; HFKL 5; HFKL5; homolog-like 15; thyroid transcription factor 2; thyroid transcription factor-2; TITF 2; TITF2; TTF 2; TTF-2; TTF2; FOXE1_HUMAN.
literatures	Specific References  (4)     |     SL0446R has been referenced in 4 publications. [IF=5.051] Lim Grace. et al. Foxe1 Deletion in the Adult Mouse is Associated with Increased Thyroidal Mast Cells and Hypothyroidism. ENDOCRINOLOGY. 2022 Sep;:  IHC, WB ;  Mouse.   PubMed:36156081 [IF=4.223] Dong, Xinwen. et al. Protective effects of curcumin against thyroid hormone imbalance after gas explosion-induced traumatic brain injury via activation of the hypothalamic-pituitary-thyroid axis in male rats. ENVIRON SCI POLLUT R. 2022 May;:1-13  WB ;  Rat.   PubMed:35641736 [IF=3.644] Ran Q et al. Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In VivoFront Endocrinol (Lausanne).2020 Dec 14;11:609697.  IF ;  Mouse.   PubMed:33381086 [IF=3.58] Wang, Qi, et al. "Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies." Food and Chemical Toxicology (2017).  WB ;  Rat.   PubMed:28341135
Research Area	transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FOXE1: 101-200/373
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Thyroid transcription factor 2 (TITF2; Forkhead; TH; also known as a "winged helix") . FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. TISSUE SPECIFICITY: Thyroid and lung. subcellular location: Nucleus Belongs to the NK-2 homeobox family. Function: Probable transcription factor. Could be involved in thyroid gland organogenesis. Subcellular Location: Nucleus (Potential). Tissue Specificity: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Post-translational modifications: Phosphorylated. DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS) [MIM:241850]. BLS is associated with thyroid agenesis, cleft palate and choanal atresia. Similarity: Contains 1 fork-head DNA-binding domain. SWISS: O00358 Gene ID: 2304 Database links: Entrez Gene: 2304 Human GenBank: NP_004464 Human Omim: 602617 Human SwissProt: O00358 Human Unigene: 159234 Human 甲状腺转录因子-2(TTF-2)在个体发生中的表达具有高度组织特异性和发育阶段特异性,是甲状腺、腭等器官正常发育的重要调节因子。 只要用于研究TTF-2基因活动规律和表达模式发生的变化,对胚胎发育过程中器官发生和产生的影响状况。
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-FOXE1 (SL0446R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 41 kD

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