Product Name	Slc22A17
Chinese Name	可溶性载质Transporter22A17抗体
Alias	24p3 receptor; 24p3R; SLC22A17; hBOIT; BOCT; BOIT; Brain type organic cation transporter; Brain-type organic cation transporter; Neutrophil gelatinase associated lipocalin receptor; Neutrophil gelatinase-associated lipocalin receptor; Lipocalin-2 receptor; NGAL receptor; NgalR; NGALR; NGALR2; NGALR3; OTTHUMP00000082690; OTTHUMP00000082691; S22AH_HUMAN; Slc22a17; Potent brain type organic ion transporter; Solute carrier family 22 member 17; Solute carrier family 22 organic cation transporter member 17.
literatures	Specific References  (4)     |     SL0444R has been referenced in 4 publications. [IF=10.199] Cui et al. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma. (2008) Clin.Cancer.Res. 14:7674-81  IHC ;  Human.   PubMed:19047093 [IF=4.24] Wu, Limin, et al. "Lipocalin‐2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron‐dependent mechanisms." Journal of Neurochemistry (2015).  WB ;  Rat.   PubMed:25557118 [IF=2.776] Du Y et al. Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One. 2019 Jul 3;14(7):e0218965.  ICC ;  Human.   PubMed:31269059 [IF=1.664] Lv et al. Overexpression of neutrophil gelatinase-associated lipocalin and its receptor in colorectal carcinoma: Significant correlation with cell differentiation and tumour invasion. (2010) Oncol.Lett. 1:103-108  IHC ;  Human.   PubMed:22966265
Research Area	Tumour  immunology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NGALR: 475-538/538
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SLC22A17 (solute carrier family 22 nember 17; organic cation transportor,).may act as a brain-specific organic ion transporter. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized. Tissue Specificity: Expressed in brain. Similarity: Belongs to the major facilitator superfamily. Organic cation transporter family. SWISS: Q8WUG5 Gene ID: 51310 Database links: Entrez Gene: 51310 Human Entrez Gene: 305886 Rat Omim: 611461 Human SwissProt: Q8WUG5 Human SwissProt: Q9P290 Rat Unigene: 373498 Human Unigene: 7312 Rat
Product Picture	Sample: Lane 1: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 2: U2os (Human) Cell Lysate at 30 ug Lane 3: U87MG (Human) Cell Lysate at 30 ug Lane 4: A549 (Human) Cell Lysate at 30 ug Lane 5: Siha (Human) Cell Lysate at 30 ug Primary: Anti-Slc22A17 (SL0444R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 61 kD Tissue/cell: rat colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Slc22A17 Y Polyclonal Antibody, Unconjugated(SL0444R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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