Product Name	TIMP-3
Chinese Name	金属蛋白酶组织抑制因子-3抗体
Alias	HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN.
literatures	Specific References  (7)     |     SL0417R has been referenced in 7 publications. [IF=5.064] Xia Liu. et al. The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway. Acta Pharmacol Sin. 2021 Apr;:1-9  WB ;  Mouse.   PubMed:33875797 [IF=4.24] Peng, Jiayin, et al. "Expression and regulative function of tissue inhibitor of metalloproteinase 3 in the goat ovary and its role in cultured granulosa cells."Molecular and Cellular Endocrinology (2015).  WB ;  Goat.   PubMed:26054746 [IF=3.98] Liu, Wen-bin, et al. "Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a." Toxicology and applied pharmacology 251.1 (2011): 70-78.  IHC-P ;  Rat.   PubMed:21163286 [IF=3.902] David Santeret al. Tenascin‐C aggravates ventricular dilatation and angiotensin‐converting enzyme activity after myocardial infarction in mice. ESC Heart Fail . 2020 Oct;7(5):2113-2122.  IHC ;  mouse.   PubMed:32639674 [IF=2.14] Lu, Minling, et al. "The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage." Cells Tissues Organs 196.3 (2012): 241-250.  IHC-P ;  Rabbit.   PubMed:22538829 [IF=1.8] Han, Jing, et al. "Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats." Biological Trace Element Research (2016): 1-9.  IHC-P ;  Rat.   PubMed:27339256 [IF=1.8] Peng, Jiayin, et al. "Expression and regulation of tissue inhibitors of metalloproteinases (TIMP1 and TIMP3) in goat oviduct." Theriogenology(2015).  IHC-P ;  Goat.   PubMed:26435260
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  Apoptosis  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TIMP-3: 151-211/211
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. Subunit: Interacts with EFEMP1. Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P35625 Gene ID: 7078 Database links: Entrez Gene: 7078 Human Entrez Gene: 21859 Mouse Entrez Gene: 25358 Rat Omim: 188826 Human SwissProt: P35625 Human SwissProt: P39876 Mouse SwissProt: P48032 Rat Unigene: 644633 Human Synthesis and Degradation（Synthesis and Degradation） 近年来，国内外科研人员对TIMP-3的抗Tumour作用日益被重视，学者认为：TIMP-3具有强烈促凋亡、抑制血管生成、抗Tumour浸润作用，TIMP-3与TIMP-1、2且相互间有明显协同抗Tumour作用
Product Picture	Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-3 Polyclonal Antibody, Unconjugated(SL0417R) 1:100, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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