Product Name	MMP3
Chinese Name	基质金属蛋白酶3抗体
Alias	MMP3_HUMAN; Stromelysin-1; EC:3.4.24.17; STMY1; SL-1; SL 1; SL1; Matrix metalloproteinase-3 (MMP-3); MMP-3; MMP 3; Transin-1;
literatures	Specific References  (23)     |     SL0413R has been referenced in 23 publications. [IF=20.722] Fanqi Hu. et al. Identification of inflammatory regulation roles of thalidomide/ruxolitinib in nucleus pulposus and construction of polyelectrolyte nanocomplexes-impregnated injectable hydrogels for synergistic intervertebral disk degeneration treatment. Nano Today. 2022 Jun;44:101462  WB ;  Human.   PubMed:10.1016/j.nantod.2022.101462 [IF=7.097] Liting Cheng. et al. Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections. Acta Pharm Sin B. 2021 May;:  IF ;  Mouse.   PubMed:10.1016/j.apsb.2021.04.020 [IF=6.832] Wu, Haibin. et al. Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway. STEM CELL RES THER. 2022 Dec;13(1):1-20  WB ;  Human.   PubMed:35619172 [IF=4.545] Kai Zhao. et al. Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model. Biomed Pharmacother. 2021 Jun;138:111466  IHC ;  Rat.   PubMed:33740525 [IF=4.162] Wenwen Chen. et al. Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification. Drug Des Dev Ther. 2021; 15: 4125–4140  IHC ;  mouse.   PubMed:34616145 [IF=3.857] Wenqiang Yan. et al. Chondral Defects Cause Kissing Lesions in a Porcine Model:. Cartilage. 0;():  IHC ;  Pig.   PubMed:32830514 [IF=3.82] Luo, Yang, et al. "Alendronate Retards the Progression of Lumbar Intervertebral Disc Degeneration in Ovariectomized Rats." Bone (2013).  IHC-P ;  Rat.   PubMed:23500174 [IF=3.269] Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862  IF,IHC ;  Human,Mouse.   PubMed:34606406 [IF=3.192] Dr. Jing Tian. et al. Downregulation of SOX21-AS1 alleviated cisplatin resistance in cervical cancer through Epithelial-messenchymal transition (EMT) inhibition. REJUV RES. 2022 Aug 30  IF, IHC ;  Human, Mouse.   PubMed:36039935 [IF=2.999] Chen CL et al. miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP 1 and MMP 3 in vitro and in vivo. FEBS Lett. 2019 Apr 12.  WB ;  Human.   PubMed:30977909 [IF=2.586] Cansu Gül Koca. et al. Effect of Single-Dose Locally Applied Lactoferrin on Autograft Healing in Peri-Implant Bone in Rat Models. Injury. 2021 Dec;:  IHC ;  Rat.   PubMed:35042599 [IF=2.535] Lei J et al. LncRNA SNHG1 Alleviates IL-1β-induced Osteoarthritis by Inhibiting miR-16-5p-mediated p38 MAPK and NF-κB Signaling Pathways. Biosci Rep. 2019 Aug 5. pii: BSR20191523.  WB ;  Human.   PubMed:31383786 [IF=2.47] Luo, Yang, et al. "The inhibitory effect of salmon calcitonin on intervertebral disc degeneration in an ovariectomized rat model." European Spine Journal (2014): 1-11.  IHC-P ;  Rat.   PubMed:25304649 [IF=2.466] Jinjiang Yang. et al. Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α. Tissue Cell. 2021 Sep;:101646  WB ;  rat.   PubMed:34536814 [IF=2.43] Wei, Fuxin, et al. "Pingyangmycin-induced in vivo lumbar disc degeneration model of rhesus monkeys." Spine 40.4 (2015): E199-E210.  IHC-P ;   PubMed:25679953 [IF=2.362] Shi, Bohui. et al. Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease. Bmc Musculoskel Dis. 2022 Dec;23(1):1-7  WB ;  Human.   PubMed:34980041 [IF=2.14] Lu, Minling, et al. "The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage." Cells Tissues Organs 196.3 (2012): 241-250.  IHC-P ;  Rabbit.   PubMed:22538829 [IF=2.049] Wang W et al. Ginkgo biloba extract may alleviate viral myocarditis by suppression of S100A4 and MMP‐3. J Med Virol. 2019 Jul 30.  IHC-P ;  Mouse.   PubMed:31359441 [IF=1.894] Bei M et al. A Novel Rat Model of Patellofemoral Osteoarthritis Due to Patella Baja, or Low-Lying Patella. Med Sci Monit. 2019 Apr 13;25:2702-2717.  IHC-P ;  Rat.   PubMed:30979862 [IF=1.8] Han, Jing, et al. "Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats." Biological Trace Element Research (2016): 1-9.  IHC-P ;  Rat.   PubMed:27339256 [IF=1.55] Yang, Jinjiang, Ying Lu, and Ai Guo. "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." Molecular Medicine Reports 14.5 (2016): 4075-4082.  WB ;  Rat.   PubMed:27665780 [IF=1.43] Wang, Xiao-yan, et al. "AMD3100 attenuates MMP-3 and MMP-9 expressions and prevents cartilage degradation in a monosodium iodoacetate-induced rat model of temporomandibular osteoarthritis." Journal of Oral and Maxillofacial Surgery (2016).  IHC-P ;  Rat.   PubMed:26851314 [IF=0.98] Koch, Holger, et al. "Tissue engineering of ureteral grafts: Preparation of biocompatible crosslinked ureteral scaffolds of porcine origin." Name: Frontiers in Bioengineering and Biotechnology 3 (2015): 89.  IHC-P ;  Pig.   PubMed:26157796
Research Area	Tumour
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42/52kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MMP3: 401-477/477
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: P08254 Gene ID: 4314 Database links: Entrez Gene: 4314 Human Entrez Gene: 17392 Mouse Entrez Gene: 171045 Rat Omim: 185250 Human SwissProt: P08254 Human SwissProt: P28862 Mouse SwissProt: P03957 Rat Unigene: 375129 Human Synthesis and Degradation（Synthesis and Degradation） 基质金属蛋白酶(matrix metalloproteinases, MMPs)是一族依赖锌离子而降解各种Extracellular matrix的蛋白酶，亦称IV型胶原酶或称明胶酶A，其主要功能为降解IV型胶原，因而它在Tumour细胞突破基底膜屏障和浸润转移中起重要作用。 MMP3目前主要用于各种恶性Tumour(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与Tumour转移浸润的研究。
Product Picture	Sample:Lymph node (Mouse) Lysate at 30 ug Primary: Anti- MMP-3 (SL0413R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42/52kD Observed band size: 52kD Sample: HepG2(Human) Cell Lysate at 30 ug Hela(Human) Cell Lysate at 30 ug Primary: Anti-MMP-3 (SL0413R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42/52 kD Observed band size: 52 kD Tissue/cell: human gastric mucosa; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MMP-3 Polyclonal Antibody, Unconjugated(SL0413R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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