Product Name	IGFBP5
Chinese Name	胰岛素样生长因子Binding protein5抗体
Alias	IBP 5; IBP5; IGF binding protein 5; IGF BP5; Insulin Like Growth Factor Binding Protein 5; IBP5_HUMAN; Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5.
literatures	Specific References  (1)     |     SL0406R has been referenced in 1 publications. [IF=0] Yamada, Koichi, et al. "Genetic and Phenotypic Changes of Thymus Tissue in Mice during Pregnancy." Journal of Oral Health and Biosciences 30.1 (2017): 26-32.  IHC-F ;  Mouse.   PubMed:JournalofOralHealthandBiosciences30.1(2017):26-32.
Research Area	Tumour  immunology  Signal transduction  Growth factors and hormones  transcriptional regulatory factor  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IGFBP5: 101-200/272
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Subcellular Location: Secreted. Tissue Specificity: Osteosarcoma, and at lower levels in liver, kidney and brain. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. SWISS: P24593 Gene ID: 3488 Database links: Entrez Gene: 3488 Human Entrez Gene: 16011 Mouse Entrez Gene: 25285 Rat Omim: 146734 Human SwissProt: P24593 Human SwissProt: Q07079 Mouse SwissProt: P24594 Rat Unigene: 607212 Human Unigene: 405761 Mouse Unigene: 1593 Rat Growth factors and hormones（ Growth Factor and Hormones） IGFBP5胰岛素样生长因子Binding protein5(IGFBP-5)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动,IGFBP-5与IGFs结合可以调节IGFs与IGF-I型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用。 有人认为：由于造骨细胞能表达与IGF-1受体截然不同的IGFBP-5受体，IGFBP-5本身也是一种生长因子，能够不依赖IGF-I独立作用来调节骨代谢。
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti- IGFBP5 (SL0406R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 30 kD Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IGFBP5 Polyclonal Antibody, Unconjugated(SL0406R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IGFBP5 Polyclonal Antibody, Unconjugated(SL0406R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human nasopharyngeal carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IGFBP5/IBP5 Polyclonal Antibody, Unconjugated(SL0406R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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