Product Name	beta 2 Microglobulin
Chinese Name	β2-微球蛋白抗体
Alias	B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta-2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092.  β2 Microglobulin; β2-Microglobulin; β-2-Microglobulin;
Research Area	Cell biology  immunology  lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13/27kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human Beta-2-Microglobulin protein
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]. Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Subunit: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Subcellular Location: Secreted. Note=Detected in serum and urine. Post-translational modifications: Glycation of Ile-21 is observed in long-term hemodialysis patients. DISEASE: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Similarity: Belongs to the beta-2-microglobulin family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SWISS: P61769 Gene ID: 567 Database links: Entrez Gene: 567 Human Entrez Gene: 12010 Mouse Entrez Gene: 24223 Rat Omim: 109700 Human SwissProt: P61769 Human SwissProt: P01887 Mouse SwissProt: P07151 Rat Unigene: 534255 Human Unigene: 702947 Human Unigene: 163 Mouse Unigene: 1868 Rat 小鼠抗人β2微球蛋白在中枢神经系统感染、Tumour及全身性自身免疫性疾病患者脑脊液中，会出现β2MG蛋白不同程度的增高。
Product Picture	Sample: Raji(Human) Cell Lysate at 30 ug Primary: Anti-beta 2 Microglobulin (SL0390R) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 13/27 kD Observed band size: 48 kD

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