Product Name	IL-6
Chinese Name	白介素6抗体
Alias	Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN.
literatures	Specific References  (31)     |     SL0379R has been referenced in 31 publications. [IF=9.112] Ho, Chia-Chi. et al. Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker. PART FIBRE TOXICOL. 2022 Dec;19(1):1-21  IHC ;  Mouse.   PubMed:35739584 [IF=7.419] Lingli Sun. et al. Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice. BIOMED PHARMACOTHER. 2022 Aug;152:113255  IHC ;  Mouse.   PubMed:35689859 [IF=7.238] Chinthalapally V. Rao. et al. GSK3‐ARC/Arg3.1 and GSK3‐Wnt signaling axes trigger amyloid‐β accumulation and neuroinflammation in middle‐aged Shugoshin 1 mice. Aging Cell. 2020 Oct;19(10):e13221  IHC ;  Mouse.   PubMed:32857910 [IF=6.529] Yizi Zhang. et al. Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice. Biomed Pharmacother. 2021 Dec;144:112268  IHC ;  Mouse.   PubMed:34634558 [IF=5.154] Erdong Yuan. et al. Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice. FOOD SCI HUM WELL. 2022 Jul;11:1053  IHC ;  Mouse.   PubMed:10.1016/j.fshw.2022.03.032 [IF=3.986] Jena PK et al. Long-term Western diet intake leads to dysregulated bile acid signaling and dermatitis with Th2 and Th17 pathway features in mice. J Dermatol Sci. 2019 Jun 8. pii: S0923-1811(19)30145-8.  WB ;  Mouse.   PubMed:31213388 [IF=3.894] Ruohong Chen. et al. Aged green tea reduces high-fat diet-induced fat accumulation and inflammation via activating the AMP-activated protein kinase signaling pathway. Food Nutr Res. 2022; 66: 10.29219/fnr.v66.7923  WB ;  Mouse.   PubMed:35382381 [IF=3.457] Kang K et al. Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway.Biomed Pharmacother. 2018 Oct;106:210-216.  WB ;  Mouse.   PubMed:29960167 [IF=3.361] Hou DD et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int Immunopharmacol. 2019 Jun 7;74:105676.  IHC-P ;  Mouse.   PubMed:31181406 [IF=3.266] Gao Y et al. Effect of splenectomy on attenuation of LPS-induced AKI through GTS-21-induced cholinergic anti-inflammatory pathway. Am J Transl Res. 2019 Apr 15;11(4):2540-2549.  WB ;  Mouse.   PubMed:31105861 [IF=3.23] Chenna Narendra S, Chalise JP, Magnusson M, Uppugunduri S (2015) Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis. PLoS ONE 10(10): e0141863  IHC-P ;  Mouse.   PubMed:26512984 [IF=3.212] Yang Gao. et al. Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway. 2020 Nov 03  WB ;  Mouse.   PubMed:33141376 [IF=3.06] Chang, Chih-Wei, et al. "Protective effects of the roots of Angelica sinensis on strenuous exercise-induced sports anemia in rats." Journal of Ethnopharmacology (2016).  IHC-P ;  Rat.   PubMed:27497636 [IF=2.882] Gul Fatma Yarim. et al. Nobiletin attenuates inflammation via modulating proinflammatory and antiinflammatory cytokine expressions in an autoimmune encephalomyelitis mouse model. Fitoterapia. 2022 Jan;156:105099  IHC ;  Rat.   PubMed:34896483 [IF=2.81] Kemmler et al. Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma. (2015) PLoS.On. 10:e0131194  IHC-P ;  Mouse.   PubMed:26147725 [IF=2.775] Sheng Deng. et al. Xuefu Zhuyu decoction improves asthma-induced asthenozoospermia based on network pharmacology and in vivo experiment. 2021 Aug 10  WB,IHC ;  Rat.   PubMed:34375006 [IF=2.48] Hong et al. Djulis (Chenopodium formosanumKoidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models. (2016) Biomed.Res.Int. 2016:7368797  IHC-P ;  Mouse.   PubMed:27847821 [IF=2.464] Zhou, Taocheng. et al. Leonurine Alleviates Alcoholic Steatohepatitis Through the TLR4/NF-κB Signalling Pathway. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy. 2022 Aug;:1-15  WB ;  Mouse.   PubMed:10.1007/s43450-022-00284-4 [IF=2.327] Qiu R et al. 20 (S)-Ginsenoside Rg3-loaded electrospun membranes to prevent postoperative peritoneal adhesion. Biomed Microdevices. 2019 Aug 14;21(4):78.  WB&IHC-P ;  Rat.   PubMed:31414228 [IF=2.31] Xi et al. Expressions of IL-6, TNF-α and NF-κB in the skin of Chinese brown frog (Rana dybowskii). (2017) Eur.J.Histochem. 61:2834  IHC-P ;  Frog.   PubMed:29313598 [IF=2.22] Ding et al. Porphyromonas gingivalis , a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice. (2018) Immun.Ageing. 15:6  IHC-P ;  Mouse.   PubMed:29422938 [IF=1.918] Wang J et al. Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network AnalysisMed Sci Monit.2020 Dec 20;26:e927491.  WB ;  Rat.   PubMed:33341820 [IF=1.662] Tianyang Huanget al. β‐Glucan ameliorates nonalcoholic steatohepatitis induced by methionine and choline‐deficient diet in mice. J Food Biochem . 2020 Jul 26;e13408.  IHC ;  mouse.   PubMed:32713066 [IF=1.58] Hong, Yong-Han, et al. "Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models." BioMed Research International 2016 (2016).  IHC-P ;  Mouse.   PubMed:doi:10.1155/2016/7368797 [IF=1.55] Wang, Yun, et al. "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." Molecular Medicine Reports 15.2 (2017): 673-680.  WB, IHC-P ;  Rat.   PubMed:28035393 [IF=1.48] Li, Kang, et al. "CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts." Molecular Medicine Reports.  other ;   PubMed:26081375 [IF=1.41] Ehrnthaller et al. C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing. (2016) Eur.J.Med.Res. 21:42  IHC-P ;  Mouse.   PubMed:27784330 [IF=1.38] Elkabir, Mohammed Ali, et al. "Efficacy of azithromycin and metronidazole combined therapy on rats’ gingival overgrowth induced by cyclosporine-A: An experimental animal study." Journal of Oral Biology and Craniofacial Research (2016).  IHC-P ;  Rat.   PubMed:27761387 [IF=1.26] Mohamed, Nesma Sultan, et al. "Impact of Three Different Mouthwashes on the Incidence of Gingival Overgrowth Induced by Cyclosporine-A; A Randomized Controlled Experimental Animal Study." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (2015).  other ;  Rat.   PubMed:26153120 [IF=0] Yamada H et al. LATE-ONSET ALZHEIMER'S DISEASE ANIMAL MODEL AND USES THEREOF. US Patent20190387723  WB, IHC-P&IHF ;  Mouse.   PubMed:US Patent20190387723
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones  Kinases and Phosphatases  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IL-6: 101-150/211
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]. Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Subcellular Location: Secreted. Post-translational modifications: N- and O-glycosylated. DISEASE: Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Similarity: Belongs to the IL-6 superfamily. SWISS: P05231 Gene ID: 3569 Database links: Entrez Gene: 3569 Human Entrez Gene: 16193 Mouse Entrez Gene: 24498 Rat Omim: 147620 Human SwissProt: P05231 Human SwissProt: P08505 Mouse SwissProt: P20607 Rat Unigene: 654458 Human Unigene: 1019 Mouse Unigene: 9873 Rat Growth factors and hormones（ Growth Factor and Hormones） 白介素-6是一种多功能cell factor，既可由lymphocyte产生，也能由非lymphocyte合成。在体内免疫反应调节、血细胞的增生、防御机制和急性期反应中起重要作用。 IL6是一种glycoprotein，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要作用，人的IL-6的前体有212个氨基酸。成熟形态为185个氨基酸。 白细胞介素6的分子量：21KD-28KD;二聚体结构（多个亚型）：42KD-56KD

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